2. Academic Validation
  3. The hepatoprotective effects of Herbt Tea Essences on phenanthrene-induced liver damage in mice

The hepatoprotective effects of Herbt Tea Essences on phenanthrene-induced liver damage in mice

  • Ecotoxicol Environ Saf. 2023 Apr 13;256:114899. doi: 10.1016/j.ecoenv.2023.114899.
Lingxiao Ye 1,  Xiaoyan Ding 1,  Changqian Liu 1,  Fengkai Ruan 1,  Hongbin Zhong 1,  Rongfu Lv 2,  Yi Yu 1,  Chengyong He 1,  Zhenghong Zuo 3,  Jiyi Huang 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Nephrology, Fujian Clinical Research Center for Chronic Glomerular Disease, The Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, Xiamen University, Xiamen, Fujian 361102, China.
  • 2 Xiamen Herbt Biotechnology Company Limited, Xiamen, Fujian 361005, China.
  • 3 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Nephrology, Fujian Clinical Research Center for Chronic Glomerular Disease, The Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: [email protected].
  • 4 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Nephrology, Fujian Clinical Research Center for Chronic Glomerular Disease, The Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: [email protected].
PMID: 37060801 DOI: 10.1016/j.ecoenv.2023.114899
Abstract

Phenanthrene (Phe), one of the most frequently occurring pollutants in nature, can cause substantial damage to the human liver. Herbt Tea Essences (HTE), a kind of black tea extract with strong anti-inflammatory activity, can protect humans against disease. Currently, whether HTE can protect the liver from Phe-induced hepatotoxicity remains unclear. Herein, we explore the protective effects of HTE against Phe-induced hepatotoxicity. Our results showed that Phe exposure could significantly induce liver damage and increase serum hepatic Enzyme levels in mice. HTE could prevent liver damage and recover the expression levels of inflammatory factors. Furthermore, we found that HTE suppressed the excessive activation of the nuclear transcription factor kappa-B and Transforming Growth Factor-β/SMAD signaling pathways to alleviate Phe-induced liver inflammation and fibrosis. Overall, our data showed that HTE treatment could be a new preventive means for Phe-induced liver disease.

Keywords

Environmental pollution; Liver damage; Phenanthrene; Tea extract.

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