2. Academic Validation
  3. Regulation of Macrophage Polarization on Chiral Potential Distribution of CFO/P(VDF-TrFE) Films

Regulation of Macrophage Polarization on Chiral Potential Distribution of CFO/P(VDF-TrFE) Films

  • ACS Biomater Sci Eng. 2023 Apr 24. doi: 10.1021/acsbiomaterials.3c00207.
Zhiyuan Zhou 1,  Jiamin Zhang 1,  Xuzhao He 1,  Xiaoyi Chen 2,  Lingqing Dong 2,  Jun Lin 3,  Huiming Wang 2,  Wenjian Weng 1,  Kui Cheng 1
Affiliations

Affiliations

  • 1 School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
  • 2 Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Province Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.
  • 3 The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
PMID: 37092816 DOI: 10.1021/acsbiomaterials.3c00207
Abstract

Surface potentials of biomaterials have been shown to regulate cell fate commitment. However, the effects of chirality-patterned potential distribution on macrophage polarization are still only beginning to be explored. In this work, we demonstrated that the chirality-patterned potential distribution of CoFe2O4/poly(vinylidene fluoride-trifluoroethylene) (CFO/P(VDF-TrFE)) films could significantly down-regulate the M1 polarization of bone marrow-derived macrophages (BMDMs). Specifically, the dextral-patterned surface potential distribution simultaneously up-regulated the expression of M2-related markers of BMDMs. The results were attributed to the sensitive difference of Integrin subunits (α5β1 and αvβ3) to the dextral- and sinistral-patterned surface potential distribution, respectively. The interaction difference between the Integrin subunits and surface potential distribution altered the cell adhesion and cytoskeletal structure and thereby the polarization behavior of BMDMs. This work, therefore, emphasizes the importance of chirality of potential distribution on cell behavior and provides a new strategy to regulate the immune response of biomaterials.

Keywords

P(VDF-TrFE); chirality patterned; immune response; surface potential.

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