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  3. Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis

Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis

  • J Mol Cell Biol. 2023 May 27;mjad035. doi: 10.1093/jmcb/mjad035.
Peng Liu 1,  Baige Cao 2,  Yang Zhou 3,  Huina Zhang 4,  Congrong Wang 2
Affiliations

Affiliations

  • 1 Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
  • 2 Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
  • 3 Tongji University, Shanghai 200092, China.
  • 4 Stem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
PMID: 37245063 DOI: 10.1093/jmcb/mjad035
Abstract

Hyperglycaemia-induced oxidative stress may disrupt Insulin secretion and β-cell survival in diabetes mellitus by overproducing Reactive Oxygen Species. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit anti-oxidant properties. However, the mechanisms by which hUC-MSCs protect β-cells from high glucose-induced oxidative stress remain underexplored. In this study, we showed that intravenous injection of hUC-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus. In vitro study revealed that hUC-MSCs attenuated high glucose-induced oxidative stress and prevented β-cell impairment via the Nrf2/HO-1 signaling pathway. Nrf2 knockdown partially blocked the anti-oxidative effect of hUC-MSCs, resulting in β-cell decompensation in a high glucose environment. Overall, these findings provide novel insights into how hUC-MSCs protect β-cells from high glucose-induced oxidative stress.

Keywords

Nrf2; mesenchymal stem cells; oxidative stress; type 1 diabetes; β-cell protection.

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