Scarless wound healing programmed by core-shell microneedles

Nat Commun. 2023 Jun 10;14(1):3431. doi: 10.1038/s41467-023-39129-6.

Ying Zhang ^# ¹, Shenqiang Wang ^# ², Yinxian Yang ¹, Sheng Zhao ¹, Jiahuan You ¹, Junxia Wang ¹, Jingwei Cai ³, Hao Wang ¹, Jie Wang ⁴, Wei Zhang ⁴, Jicheng Yu ¹ ³ ⁵ ⁶ ⁷, Chunmao Han ⁴, Yuqi Zhang ⁸ ⁹ ¹⁰, Zhen Gu ¹¹ ¹² ¹³ ¹⁴ ¹⁵ ¹⁶

Affiliations

1 Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
2 Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. [email protected].
3 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, China.
4 Department of Burns and Wound Care Center, the Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009, Hangzhou, China.
5 Jinhua Institute of Zhejiang University, 321299, Jinhua, China.
6 Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
7 National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China.
8 Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. [email protected].
9 Department of Burns and Wound Care Center, the Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009, Hangzhou, China. [email protected].
10 National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China. [email protected].
11 Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. [email protected].
12 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, China. [email protected].
13 Jinhua Institute of Zhejiang University, 321299, Jinhua, China. [email protected].
14 Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China. [email protected].
15 National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China. [email protected].
16 MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. [email protected].
# Contributed equally.

PMID: 37301874 DOI: 10.1038/s41467-023-39129-6

Abstract

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant Bacterial biofilm at the early stage via generating Reactive Oxygen Species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models.

Products

Cat. No.

Product Name

Description

Target

Research Area
HY-D0940

H2DCFDA

99.82%, Redox-Sensitive Probe

Reactive Oxygen Species

Others

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