2. Academic Validation
  3. Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

  • Nat Commun. 2023 Sep 14;14(1):5699. doi: 10.1038/s41467-023-41389-1.
Sarun Juengpanich # 1 2 3,  Shijie Li # 1 2,  Taorui Yang # 4,  Tianao Xie 1 2,  Jiadong Chen 5,  Yukai Shan 1,  Jiyoung Lee 6,  Ziyi Lu 1,  Tianen Chen 1,  Bin Zhang 1,  Jiasheng Cao 1,  Jiahao Hu 1,  Jicheng Yu 1 6 7 8 9,  Yanfang Wang 6,  Win Topatana 10 11,  Zhen Gu 12 13 14 15 16 17,  Xiujun Cai 18 19 20,  Mingyu Chen 21 22 23
Affiliations

Affiliations

  • 1 Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.
  • 2 School of Medicine, Zhejiang University, 310058, Hangzhou, China.
  • 3 National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.
  • 4 Department of Chemistry, Zhejiang Sci-Tech University, 310018, Hangzhou, China.
  • 5 Department of Chemistry, Zhejiang University, 310016, Hangzhou, China.
  • 6 Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.
  • 7 National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China.
  • 8 Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China.
  • 9 Jinhua Institute of Zhejiang University, 321299, Jinhua, China.
  • 10 Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • 11 School of Medicine, Zhejiang University, 310058, Hangzhou, China. [email protected].
  • 12 Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • 13 Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China. [email protected].
  • 14 National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 310058, Hangzhou, China. [email protected].
  • 15 Liangzhu Laboratory, Zhejiang University Medical Center, 311121, Hangzhou, China. [email protected].
  • 16 Jinhua Institute of Zhejiang University, 321299, Jinhua, China. [email protected].
  • 17 MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. [email protected].
  • 18 Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • 19 School of Medicine, Zhejiang University, 310058, Hangzhou, China. [email protected].
  • 20 National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • 21 Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • 22 School of Medicine, Zhejiang University, 310058, Hangzhou, China. [email protected].
  • 23 National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China. [email protected].
  • # Contributed equally.
PMID: 37709778 DOI: 10.1038/s41467-023-41389-1
Abstract

Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy. STPNs are initially stimulated by NIR irradiation before intravenous administration and accumulate at the tumor site to enter the cells through the HER2 receptor. Due to Pu18 afterglow luminescence properties, STPNs can continuously generate ROS to inhibit NFκB nuclear translocation, leading to tumor cell Apoptosis. Moreover, STPNs can be used for diagnostic purposes through MRI and intraoperative NIR navigation. STPNs exceptional antitumor properties combined the advantages of UCNPs and persistent luminescence, representing a promising phototherapeutic strategy for deep tumors.

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