2. Academic Validation
  3. The nucleolar protein NIFK accelerates the progression of colorectal cancer via activating MYC pathway

The nucleolar protein NIFK accelerates the progression of colorectal cancer via activating MYC pathway

  • Biosci Biotechnol Biochem. 2023 Nov 9:zbad157. doi: 10.1093/bbb/zbad157.
Tingting Xia 1,  Bin Wang 1,  Lingling Sun 1
Affiliations

Affiliation

  • 1 Oncology Department, Zibo First Hospital, Zibo, Shandong, China.
PMID: 37950567 DOI: 10.1093/bbb/zbad157
Abstract

This study aimed to explore the function of NIFK on colorectal Cancer (CRC) and its associated molecular mechanisms. NIFK was upregulated in CRC tissues and cells. NIFK silencing resulted in reduced cell growth and metastasis, as well as in promoted Apoptosis in CRC cells. Moreover, NIFK silencing was also confirmed to inhibit lipid accumulation and decrease fatty acid synthesis via downregulating lipogenic enzymes in CRC cells. Gene Set Enrichment Analysis and western blot co-verified that NIFK silencing inhibited MYC pathway in CRC cells. In addition, we also revealed that NIFK silencing function on cell growth, Apoptosis, metastasis and fatty acid metabolism in CRC might be cancelled after c-Myc overexpression. Silencing NIFK could inhibit cell growth and metastasis, and promoted Apoptosis, as well as regulated fatty acid metabolism by inhibiting MYC pathway in CRC.

Keywords

CRC; MYC; NIFK; fatty acid metabolism.

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