2. Academic Validation
  3. Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier

Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier

  • Int Immunopharmacol. 2023 Nov 22:126:111188. doi: 10.1016/j.intimp.2023.111188.
Minxuan Xu 1,  Fang Shi 2,  Yongshen Gao 2,  Shumei Han 2,  Chensuo Huang 2,  Qinsheng Hou 2,  Xiaoweng Wen 2,  Bengshi Wang 2,  Zhenyu Zhu 2,  Lei Zou 3,  Mingxin Xiong 4,  Wei Dong 5,  Jun Tan 6
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, 400067 Chongqing, PR China. Electronic address: [email protected].
  • 2 New Drug Technology R&D Center, Nanjing Biomed Sciences Inc., 210003 Nanjing, PR China.
  • 3 New Drug Technology R&D Center, Nanjing Biomed Sciences Inc., 210003 Nanjing, PR China. Electronic address: [email protected].
  • 4 Technology R&D Center, Chongqing Tianwai TIAN Medical Instrument Co., Ltd., 400067 Chongqing, PR China.
  • 5 Department of Gastroenterology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong Province, 250117, PR China.
  • 6 Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, 400067 Chongqing, PR China. Electronic address: [email protected].
PMID: 37995573 DOI: 10.1016/j.intimp.2023.111188
Abstract

There is a growing amount of research that highlights the significant involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. Arabinose is a naturally occurring bioactive monosaccharide that plays a crucial role in the metabolic processes and synthesis of many compounds in living organisms. However, the more detailed molecular mechanism by which the administration of arabinose alleviates the progression of colitis and its associated carcinogenesis is still not fully understood. In the present study, arabinose is recognized as a significant and inherent protector of the intestinal mucosal barrier through its role in preserving the integrity of tight junctions within the intestines. Also, it is important to note that there is a positive correlation between the severity of inflammatory bowel disease (IBD) and colorectal Cancer (CRC), as well as chemically-induced colitis in mice, and lower levels of arabinose in the bloodstream. In two mouse models of colitis, caused by dextran sodium sulfate (DSS) or by spontaneous colitis in IL-10-/- mice, damage to the intestinal mucosa was reduced by giving the mice arabinose. When arabinose is administrated to model with colitis, it sets off a chain of events that help keep the lysosomes together and stop Cathepsin B from being released. During the progression of intestinal epithelial injury, this process blocks Myosin light chain kinase (MLCK) from damaging tight junctions and causing mitochondrial dysfunction. In summary, the results of the study have provided evidence supporting the beneficial effects of arabinose in mitigating the progression of colitis. This is achieved through its ability to avoid dysregulation of the intestinal barrier. Consequently, arabinose may hold promise as a therapeutic supplementation for the management of colitis.

Keywords

Arabinose; Colitis; Dextran sodium sulfate (DSS); Inflammatory bowel diseases (IBD); Intestinal epithelial cells.

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