2. Academic Validation
  3. Antiparasitic nitazoxanide potentiates colistin against colistin-resistant Acinetobacter baumannii and Escherichia coli in vitro and in vivo

Antiparasitic nitazoxanide potentiates colistin against colistin-resistant Acinetobacter baumannii and Escherichia coli in vitro and in vivo

  • Microbiol Spectr. 2023 Nov 30:e0229523. doi: 10.1128/spectrum.02295-23.
Mengxin Xu # 1 2,  Zhuocheng Yao # 1,  Jingchun Kong 3,  Miran Tang 1,  Qi Liu 1,  Xiaotuan Zhang 1,  Shiyi Shi 1,  Xiangkuo Zheng 1,  Jianming Cao 3,  Tieli Zhou 1,  Zhongyong Wang 1
Affiliations

Affiliations

  • 1 Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou, China.
  • 2 Department of Clinical Laboratory, Laboratory Medicine Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • 3 Department of Medical Lab Science, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.
  • # Contributed equally.
PMID: 38032179 DOI: 10.1128/spectrum.02295-23
Abstract

Colistin is used as a last resort in many infections caused by multidrug-resistant Gram-negative bacteria; however, colistin-resistant (COL-R) is on the rise. Hence, it is critical to develop new antimicrobial strategies to overcome COL-R. We found that nitazoxanide (NTZ) combined with colistin showed notable synergetic Antibacterial activity. These findings suggest that the NTZ/colistin combination may provide an effective alternative route to combat COL-R A. baumannii and COL-R Escherichia coli infections.

Keywords

Acinetobacter baumannii; Escherichia coli; colistin-resistant; drug repurposing; nitazoxanide; synergistic effect.

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