2. Academic Validation
  3. Management of non-compressible hemorrhage and re-bleeding by a liquid hemostatic polysaccharide floccuronic acid

Management of non-compressible hemorrhage and re-bleeding by a liquid hemostatic polysaccharide floccuronic acid

  • Int J Biol Macromol. 2023 Dec 8:128695. doi: 10.1016/j.ijbiomac.2023.128695.
Shijunyin Chen 1,  Changchang Kong 1,  Ning Yu 1,  Xiaodong Xu 1,  Bing Li 2,  Jianfa Zhang 3
Affiliations

Affiliations

  • 1 Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China; Key laboratory of Metabolic Engineering and Biosynthesis Technology, Ministry of industry and information technology, 210094, China.
  • 2 Nanjing Southern Element Biotechnology Co., Ltd, Nanjing 211899, China.
  • 3 Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China; Key laboratory of Metabolic Engineering and Biosynthesis Technology, Ministry of industry and information technology, 210094, China. Electronic address: [email protected].
PMID: 38072343 DOI: 10.1016/j.ijbiomac.2023.128695
Abstract

Effective management of excessive bleeding requires liquid hemostatic agents, especially in scenarios involving uncompressible and postoperative hemorrhage. This study introduces the microbial exopolysaccharide floccuronic acid (FA) as a liquid hemostatic agent, characterized by a high weight average molecular weight of 2.38 × 108 Da. The investigation focuses on the flocculation effect, hemostatic efficiency in both in vitro and in vivo settings, elucidating its hemostatic mechanism, and assessing its safety profile. Results reveal that FA solution significantly accelerates the coagulation process, leading to the formation of compact clots while specifically interfering with fibrin. Notably, FA demonstrates excellent hemostatic effects in animal liver models and a rat arterial rebleeding model. The biocompatible and biodegradable characteristics further underscore FA's potential as a valuable liquid hemostatic material, particularly suited for non-compressible and re-bleeding scenarios.

Keywords

Fibrin; Hemostasis; Polysaccharide.

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