2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Mexiletine-d6 hydrochloride

Mexiletine-d6 hydrochloride  (Synonyms: KOE-1173-d6 (hydrochloride))

Cat. No.: HY-A0093S Purity: 99.88%
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Mexiletine-d6 (hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1].

For research use only. We do not sell to patients.

Mexiletine-d<sub>6</sub> hydrochloride Chemical Structure

Mexiletine-d6 hydrochloride Chemical Structure

CAS No. : 1329835-60-0

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1 mg USD 568 In-stock
5 mg USD 1250 In-stock
10 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

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Mexiletine-d6 hydrochloride Related Antibodies

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Description

Mexiletine-d6 (hydrochloride) is a deuterium labeled Mexiletine hydrochloride (KOE-1173 hydrochloride). Mexiletine hydrochloride, a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1].

Molecular Weight

221.76

Formula

C11H12D6ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC(C)=C1OC([2H])([2H])C(N)([2H])C([2H])([2H])[2H].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (225.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5094 mL 22.5469 mL 45.0938 mL
5 mM 0.9019 mL 4.5094 mL 9.0188 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5094 mL 22.5469 mL 45.0938 mL 112.7345 mL
5 mM 0.9019 mL 4.5094 mL 9.0188 mL 22.5469 mL
10 mM 0.4509 mL 2.2547 mL 4.5094 mL 11.2734 mL
15 mM 0.3006 mL 1.5031 mL 3.0063 mL 7.5156 mL
20 mM 0.2255 mL 1.1273 mL 2.2547 mL 5.6367 mL
25 mM 0.1804 mL 0.9019 mL 1.8038 mL 4.5094 mL
30 mM 0.1503 mL 0.7516 mL 1.5031 mL 3.7578 mL
40 mM 0.1127 mL 0.5637 mL 1.1273 mL 2.8184 mL
50 mM 0.0902 mL 0.4509 mL 0.9019 mL 2.2547 mL
60 mM 0.0752 mL 0.3758 mL 0.7516 mL 1.8789 mL
80 mM 0.0564 mL 0.2818 mL 0.5637 mL 1.4092 mL
100 mM 0.0451 mL 0.2255 mL 0.4509 mL 1.1273 mL
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Mexiletine-d6 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mexiletine-d61329835-60-0KOE-1173-d6Sodium ChannelNa channelsNa+ channelsdeuteriumantiarrhythmicClass IBmyocardialischemiaInhibitorinhibitorinhibit

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