Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Monomethyl auristatin E

HY-15162

(Vedotin; MMAE)

Monomethyl auristatin E

Monomethyl auristatin E Chemical Structure

Monomethyl auristatin E (MMAE; Vedotin) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $426 In-stock
1 mg $100 In-stock
5 mg $270 In-stock
10 mg $440 In-stock
50 mg $1000 In-stock
100 mg $1700 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €417 In-stock
1 mg €98 In-stock
5 mg €265 In-stock
10 mg €431 In-stock
50 mg €980 In-stock
100 mg €1666 In-stock
200 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: Monomethyl auristatin E
Cat. No.: HY-15162

Monomethyl auristatin E Data Sheet

  • View current batch:

    Purity: 99.92%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Customer View

Related Compound Libraries

Biological Activity of Monomethyl auristatin E

Monomethyl auristatin E (MMAE) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. 
IC50 Value: N/A
Target:  ADCs cytotoxin; Microtubule/Tubulin
For example VcMMAE, an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.

Chemical Information

M.Wt 717.98 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C39H67N5O7
CAS No 474645-27-7
Solvent & Solubility

DMSO:48mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.3928 mL 6.9640 mL 13.9280 mL
5 mM 0.2786 mL 1.3928 mL 2.7856 mL
10 mM 0.1393 mL 0.6964 mL 1.3928 mL

References on Monomethyl auristatin E

Other Forms

Inhibitor Kit
  • 10-Deacetyl-7-xylosyl paclitaxel

    10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

  • 4'-Demethylepipodophyllotoxin

    4(acute)-Demethylepipodophyllotoxin(4(acute)-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.

  • 7-xylosyltaxol

    7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

  • ABT-751

    ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 (mu)M in neuroblastoma and non-neuroblastoma cell lines, respectively.

  • alpha-Amanitin

    alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.

  • Ansamitocin P 3'

    Ansamitocin P 3(acute) exhibits antitumour activity, is an antibody drug conjugate cytotoxin.

  • Ansamitocin P-3

    Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29; Antibody drug conjugate cytotoxin.

  • Auristatin E

    Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

  • Auristatin F

    Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

  • BNC105

    BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

MORE