2. Membrane Transporter/Ion Channel
  3. Sodium Channel Potassium Channel
  4. Nav1.8-IN-7

Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.

For research use only. We do not sell to patients.

Nav1.8-IN-7 Chemical Structure

Nav1.8-IN-7 Chemical Structure

CAS No. : 2761181-58-0

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Nav1.8-IN-7 Related Antibodies

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Description

Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1].

In Vitro

Nav1.8-IN-9 (Example 116; 1 μM) shows inhibitions of 1.2％, 3.7％, <1％, <1％, 2.6％, <1％ for Nav1.1, Nav1.3, Nav1.4, Nav1.5, Nav1.6, and Nav1.7, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nav1.8-IN-7 Related Antibodies
In Vivo

Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats[1].

PO (100 mg/kg)
Cmax (ng/mL) 2566
AUC0-24 (ng/mL∗h) 42454
t1/2 (h) 8.7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

515.84

Formula

C22H18ClF4N3O5
CAS No.
SMILES

OC[C@@H](O)COC1=CC(NC(C(C=C(C(C(F)(F)F)=C2)Cl)=C2OC3=C(C=C(C=C3)F)C)=O)=CN=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    5％ DMSO + 95％ saline 对受试化合物进行混悬，并经涡旋 2 min，超声 5min 之后配制成给药体系。

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Nav1.8-IN-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.8-IN-72761181-58-0Sodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAOrallyNav1.8painInhibitorinhibitorinhibit

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