2. Metabolic Enzyme/Protease
  3. Elastase
  4. Neutrophil elastase inhibitor 4

Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells.

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Neutrophil elastase inhibitor 4 Chemical Structure

Neutrophil elastase inhibitor 4 Chemical Structure

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Neutrophil elastase inhibitor 4 Related Antibodies

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Description

Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC50: 42.30 nM, Ki: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC50s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells[1].

IC50 & Target

42.30 nM human neutrophil elastase[1]
Molecular Weight

383.40

Formula

C20H21N3O5
SMILES

O=C(C(N(CC1=C2C=CC=C1N3C(C(CC)(CC)C3=O)=O)C2=O)CC4)NC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neutrophil elastase inhibitor 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neutrophil elastase inhibitor 4Neutrophil elastase inhibitor4Neutrophil elastase inhibitor-4ElastaseAntiproliferativecancerT47DRPMI 8226A549HSF cellInhibitorinhibitorinhibit

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