2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NSC 90469

NSC 90469  (Synonyms: 3,5-Diiodo-L-thyronine)

Cat. No.: HY-114557 Purity: 99.38%
COA Handling Instructions

Molarity Calculator

NSC 90469 is an endogenous metabolite.

For research use only. We do not sell to patients.

NSC 90469 Chemical Structure

NSC 90469 Chemical Structure

CAS No. : 1041-01-6

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Based on 1 publication(s) in Google Scholar

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Description

NSC 90469 is an endogenous metabolite.

Molecular Weight

525.08

Formula

C15H13I2NO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C=C2)C(O)=O.[(s)]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

Ethanol : 22.22 mg/mL (42.32 mM; ultrasonic and adjust pH to 2 with 1M HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9045 mL 9.5224 mL 19.0447 mL
5 mM 0.3809 mL 1.9045 mL 3.8089 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.22 mg/mL (4.23 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.22 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (22.2 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.22 mg/mL (4.23 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.22 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (22.2 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.9045 mL 9.5224 mL 19.0447 mL 47.6118 mL
5 mM 0.3809 mL 1.9045 mL 3.8089 mL 9.5224 mL
10 mM 0.1904 mL 0.9522 mL 1.9045 mL 4.7612 mL
15 mM 0.1270 mL 0.6348 mL 1.2696 mL 3.1741 mL
20 mM 0.0952 mL 0.4761 mL 0.9522 mL 2.3806 mL
25 mM 0.0762 mL 0.3809 mL 0.7618 mL 1.9045 mL
30 mM 0.0635 mL 0.3174 mL 0.6348 mL 1.5871 mL
40 mM 0.0476 mL 0.2381 mL 0.4761 mL 1.1903 mL
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NSC 90469 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 904691041-01-63,5-Diiodo-L-thyronineNSC90469NSC-90469Endogenous MetaboliteInhibitorinhibitorinhibit

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