2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. NUCC-0226272

NUCC-0226272 is a potent PROTAC that targets EZH2 for degradation. NUCC-0226272 has anti-proliferative effect. NUCC-0226272 has the potential for cancer research.

For research use only. We do not sell to patients.

NUCC-0226272 Chemical Structure

NUCC-0226272 Chemical Structure

CAS No. : 3004503-12-9

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5 mg USD 437 In-stock
10 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

NUCC-0226272 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NUCC-0226272 is a potent PROTAC that targets EZH2 for degradation. NUCC-0226272 has anti-proliferative effect. NUCC-0226272 has the potential for cancer research[1].

IC50 & Target[1]

EZH2

 

In Vitro

NUCC-0226272 (0.01-10 μM; 5 days) shows anti-proliferative effect in LNCaP and 22Rv1 cells[1].
NUCC-0226272 (10 μM; 6 days) shows strong degradation of EZH2, as well as reduction of PRC2 component SUZ12, and reduced H3K27me3 levels in C4-2B cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NUCC-0226272 Related Antibodies
In Vivo

Pharmacokinetic Parameters of NUCC-0226272 in C57Bl/6 mouse[1].

IP (4 mg/kg)
Tmax (h) 0.83
Cmax (ng/mL) 3650
AUClast (min·ng/mL) 12777389
t1/2 (h) 3.46
CL (mL/min/kg) 3.11
Vss (L/kg) 3.11

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1182.56

Formula

C67H91N9O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 140 mg/mL (118.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8456 mL 4.2281 mL 8.4562 mL
5 mM 0.1691 mL 0.8456 mL 1.6912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8456 mL 4.2281 mL 8.4562 mL 21.1406 mL
5 mM 0.1691 mL 0.8456 mL 1.6912 mL 4.2281 mL
10 mM 0.0846 mL 0.4228 mL 0.8456 mL 2.1141 mL
15 mM 0.0564 mL 0.2819 mL 0.5637 mL 1.4094 mL
20 mM 0.0423 mL 0.2114 mL 0.4228 mL 1.0570 mL
25 mM 0.0338 mL 0.1691 mL 0.3382 mL 0.8456 mL
30 mM 0.0282 mL 0.1409 mL 0.2819 mL 0.7047 mL
40 mM 0.0211 mL 0.1057 mL 0.2114 mL 0.5285 mL
50 mM 0.0169 mL 0.0846 mL 0.1691 mL 0.4228 mL
60 mM 0.0141 mL 0.0705 mL 0.1409 mL 0.3523 mL
80 mM 0.0106 mL 0.0529 mL 0.1057 mL 0.2643 mL
100 mM 0.0085 mL 0.0423 mL 0.0846 mL 0.2114 mL
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NUCC-0226272 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NUCC-02262723004503-12-9NUCC0226272NUCC 0226272PROTACsHistone MethyltransferaseInhibitorinhibitorinhibit

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