1. Protein Tyrosine Kinase/RTK
  2. Btk

PCI 29732 

Cat. No.: HY-18010
Handling Instructions

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

For research use only. We do not sell to patients.
PCI 29732 Chemical Structure

PCI 29732 Chemical Structure

CAS No. : 330786-25-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $132 In-stock
5 mg $120 In-stock
10 mg $180 In-stock
50 mg $720 In-stock
100 mg $1300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. IC50 value: 8.2 nM [1] Target: Btk kinase PCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1]. In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6922 mL 13.4611 mL 26.9222 mL
5 mM 0.5384 mL 2.6922 mL 5.3844 mL
10 mM 0.2692 mL 1.3461 mL 2.6922 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

371.44

Formula

C₂₂H₂₁N₅O

CAS No.

330786-25-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 53 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PCI 29732
Cat. No.:
HY-18010
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