2. Protein Tyrosine Kinase/RTK Apoptosis Cell Cycle/DNA Damage
  3. Src Bcr-Abl Apoptosis Wee1
  4. PD173952

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.

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PD173952 Chemical Structure

PD173952 Chemical Structure

CAS No. : 305820-75-1

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Based on 1 publication(s) in Google Scholar

PD173952 Related Antibodies

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Description

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].

IC50 & Target[1][2]

Lyn

0.3 nM (IC50)

Abl

1.7 nM (IC50)

Csk

6.6 nM (IC50)

Myt1

8.1 nM (Ki)

In Vitro

PD173952 (0-1000 nM; 12 h) inhibits tyrosine phosphorylation of p210Bcr-Abl and CrkL in K562 cells in a concentration-dependent manner[1].
PD173952 (0.5 μM; 1-4 days) inhibits K562 cell viability[1].
PD173952 (0.5 μM; 24 and 48 h) induces apoptosis of K562 and MEG-01 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD173952 Related Antibodies

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 0, 25, 50, 100, 200, 500 and 1000 nM
Incubation Time: 12 h
Result: Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL.

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 0.5 μM
Incubation Time: 1-4 days
Result: Caused cell death in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: K562 and MEG-01 cells
Concentration: 0.5 μM
Incubation Time: 24 and 48 h
Result: 85-kDa PARP fragment was detected.
Molecular Weight

482.36

Formula

C24H21Cl2N5O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C2=C(C=CC=C2Cl)Cl)=CC3=CN=C(N=C3N1C)NC4=CC=C(C=C4)N5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PD173952 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD173952305820-75-1PD 173952PD-173952SrcBcr-AblApoptosisWee1LynAblCskMyt1K562MEG-01Inhibitorinhibitorinhibit

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