2. Apoptosis
  3. MDM-2/p53
  4. PK9327

PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

For research use only. We do not sell to patients.

PK9327 Chemical Structure

PK9327 Chemical Structure

CAS No. : 2413987-20-7

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Based on 1 publication(s) in Google Scholar

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Description

PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

Molecular Weight

334.48

Formula

C21H22N2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=CC=C(C2=CC3=C(C=C2)C4=C(C=CC(CNC)=C4)N3CC)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (29.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9897 mL 14.9486 mL 29.8972 mL
5 mM 0.5979 mL 2.9897 mL 5.9794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9897 mL 14.9486 mL 29.8972 mL 74.7429 mL
5 mM 0.5979 mL 2.9897 mL 5.9794 mL 14.9486 mL
10 mM 0.2990 mL 1.4949 mL 2.9897 mL 7.4743 mL
15 mM 0.1993 mL 0.9966 mL 1.9931 mL 4.9829 mL
20 mM 0.1495 mL 0.7474 mL 1.4949 mL 3.7371 mL
25 mM 0.1196 mL 0.5979 mL 1.1959 mL 2.9897 mL
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PK9327 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PK93272413987-20-7PK 9327PK-9327MDM-2/p53Inhibitorinhibitorinhibit

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