2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT5-IN-28

PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape.

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PRMT5-IN-28 Chemical Structure

PRMT5-IN-28 Chemical Structure

CAS No. : 2242753-66-6

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PRMT5-IN-28 Related Antibodies

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Description

PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape[1].

IC50 & Target[1]

PRMT5

 

Molecular Weight

406.82

Formula

C18H19ClN4O5
CAS No.
SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@]1([H])[C@@H](C(C=C2)=CC=C2Cl)O)N3C(NC=N/C4=N\OC)=C4C=C3
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PRMT5-IN-28 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-282242753-66-6Histone MethyltransferaseProtein arginine methylationpost-translational modificationtranscriptionmRNA splicingDNA repairprotein cellular localizationcell fate determinationresist apoptosisinvasionmetastasisimmune escapeInhibitorinhibitorinhibit

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