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  4. PRO-905

Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .

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PRO-905 Chemical Structure

PRO-905 Chemical Structure

CAS No. : 2762209-68-5

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Description

Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) [1].

In Vitro

Pro-905 (10 µM, 120 h) inhibits cell proliferation and guanine incorporation to newly synthesized DNA and RNA using JH-2-002 cells with JHU395 (HY-124778) 1 µM, 120 h[1].
Pro-905 (10 µM, 120 h) inhibits colony formation in sNF96.2 and JH-2-002 human MPNST cell with JHU395 (1 µM, 120 h)[1].
Pro-905 (10 µM, 6 h) inhibits purine salvage-dependent 3H-hypoxanthine incorporation to DNA and RNA in sNF96.2 cells[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRO-905 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: sNF96.2 and JH-2-002 human MPNST cells
Concentration: 10 µM (in combination with JHU395 (HY-124778)(1µM))
Incubation Time: 120 h
Result: Inhibited cell proliferation with effects on nucleic acid and induced DNA damage (γH2AX).
In Vivo

Pro-905 (20 mg/kg, i.p., 5 days per week for 4 weeks ) slows tumor growth in Nod cid gamma (NSG) mice models bearing the human MPNST PDX JH-2-031[1].
Pro-905 (10 mg/kg, i.p, 5 d/week) in B6 mice with flank MPNST inhibits tumor nucleotide metabolism and abrogates MPNST proliferation with JHU395 (1.2 mg/kg, p.o.) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6 mice with flank MPNST[1]
Dosage: 10 mg/kg (in combination with JHU3955 (1.2 mg/kg, p.o.))
Administration: Intraperitoneal injection
Result: Prevented growth of established tumors to a greater extent.
Induced tumors significantly decrease, mean percent proliferation, JHU395 0.82%, Pro-905 1.25%, combination 0.18%.
Animal Model: Nod scid gamma (NSG) mice with JH-2-031 MPNST [1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection
Result: Caused animal body weights remained within 10% of starting weights over two weeks of dosing.
Molecular Weight

568.54

Formula

C22H29N6O8PS
CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=S)=C3N=C2)O[C@@H]1COP(N[C@H](C(OC(C)C)=O)C)(OC4=CC=CC=C4)=O
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References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRO-9052762209-68-5MK-905PRO905PRO 905MK905MK 905OtherssNF96.2 cellsJH-2-002 cellsNPcis miceWild-type C57BL/6 male miceMPNSTnucleic acidcolony formationpurine salvageInhibitorinhibitorinhibit

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