2. PROTAC Neuronal Signaling GPCR/G Protein Apoptosis
  3. PROTACs Adrenergic Receptor Apoptosis
  4. PROTAC AR/AR-V7 degrader-1

PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker).

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PROTAC AR/AR-V7 degrader-1 Chemical Structure

PROTAC AR/AR-V7 degrader-1 Chemical Structure

CAS No. : 2841308-96-9

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PROTAC AR/AR-V7 degrader-1 Related Antibodies

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Description

PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].
In Vitro

PROTAC AR/AR-V7 degrader-1 (27c) effectively suppresses transcriptional activity of the AR signaling pathway. PROTAC AR/AR-V7 degrader-1 (27c) exhibits an IC50 of 0.9 μM in 22RV1 cells[1].
PROTAC AR/AR-V7 degrader-1 (27c) overcomes drug resistance in advanced PCa expressing AR splice variants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC AR/AR-V7 degrader-1 Related Antibodies
Molecular Weight

485.43

Formula

C24H19F4N5O2
CAS No.
Unlabeled Cas

SMILES

O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC AR/AR-V7 degrader-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AR/AR-V7 degrader-12841308-96-9PROTACsAdrenergic ReceptorApoptosisBeta ReceptorARAR-V7PCa22RV1,Inhibitorinhibitorinhibit

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HY-162412
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