2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. PROTAC BTK Degrader-5

PROTAC BTK degraders-5(compound 3e) is a selective BTK degrader with a DC50 value of 7.0 nM in JeKo-1 cells. PROTAC BTK degraders-5 has no off-target effect on degrading CRBN neosubstates. PROTAC BTK degraders-5 has anti-proliferation effect on various lymphoma tumor cells and can be used in chronic lymphoid malignancies research1.

For research use only. We do not sell to patients.

PROTAC BTK Degrader-5 Chemical Structure

PROTAC BTK Degrader-5 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PROTAC BTK Degrader-5 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC BTK degraders-5(compound 3e) is a selective BTK degrader with a DC50 value of 7.0 nM in JeKo-1 cells. PROTAC BTK degraders-5 has no off-target effect on degrading CRBN neosubstates. PROTAC BTK degraders-5 has anti-proliferation effect on various lymphoma tumor cells and can be used in chronic lymphoid malignancies research1.

In Vitro

PROTAC BTK Degrader-5 (Compound 3e) (1.6~1000 nM; 24 h) induces BTK degradation with DC50 value of 7.0 nM in JeKo-1 cells[1].
PROTAC BTK Degrader-5 (100 and 1000 nM) possesses the metabolic stability with the T1/2 of 145 min[1].
PROTAC BTK Degrader-5 (100 nM;12 h) induced - BTK degradation blocks by proteasome inhibitor MG - 132 (HY-13259) (5 μM)[1].
PROTAC BTK Degrader-5 (1.6~1000 nM; 24 h) has no effect on the levels of IKZF1 and GSPT1 and mild effect on the level of IKZF3[1].
PROTAC BTK Degrader-5 (72 h) has anti- proliferation effect in OCI-ly10, TMD8, JeKo-1 and BTK C481S Ba/F3 cells with the IC50 values of 2.3, 4.5, 38.1 and 86.0 nM, which were higher than Ibrutinib (HY-10997)(IC50 value of 4.5, 4.7, 79.8, and 1546.0 nM, respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BTK Degrader-5 Related Antibodies
In Vivo

PROTAC BTK Degrader-5 (2 mg/kg for i.v, sigle dose) is metabolically stable in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The male Balb/c mice[1]
Dosage: a single dose 2 mg/kg or 100 mg/kg, 5% DMSO, 10% Solutol, 85% saline
Administration: Intravenous injection (i.v.); Oral gavage (p.o.)
Result: Maintained above 10 nM for at least 4 h after administration of PROTAC BTK Degrader-5 at a single dose of 2 mg/kg via intravenous (IV) injection in the plasma (the effective BTK degradation DC5050 = 7.0nM).
Had poor oral bioavailability at a dose of 100 mg/kg.
Molecular Weight

958.52

Formula

C52H57ClFN9O6
SMILES

O=C(C1=C(Cl)C=C(OC2=CC=CC=C2)C=C1)C3=CNC4=NC=NC(N[C@@H]5CC[C@H](NC(CC6CCN(CCC7CCN(C8=C(F)C=C(C(N(C9CCC(NC9=O)=O)C%10)=O)C%10=C8)CC7)CC6)=O)CC5)=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PROTAC BTK Degrader-5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BTK Degrader-5PROTAC BTK Degrader5PROTAC BTK Degrader 5BtkBruton tyrosine kinaseJeKo-1OCI-ly10TMD8BTK C481S Ba/F3lymphoma cancers,Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC BTK Degrader-5
Cat. No.:
HY-155072
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.