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Products are for research use only. Not for human use. We do not sell to patients.
(PTC209; PTC 209)
PTC-209 Chemical Structure
|Product name: PTC-209|
|Cat. No.: HY-15888|
PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays.
IC50 value: 0.5 uM 
PTC-209 inhibited not only the UTR-mediated reporter expression but also endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 caused no inhibition of cell growth or viability in HEK293 human embryonic kidney cells after overnight treatment and had limited effects on cell proliferation in HT1080 cells after a 48-h treatment. PTC-209 selectively reduced global ubiquitinated histone H2A (uH2A) but not total H2A and RING1A levels indicating its ability to specifically reduce PRC1 activity. Compound PTC-209 preferentially inhibits the proliferation of human lymphoma U937 and HT1080 tumor cells, whereas it is lesseffective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells.
|M.Wt||495.19||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: 42 mg/ml
|1 mg||5 mg||10 mg|
|1 mM||2.0194 mL||10.0971 mL||20.1943 mL|
|5 mM||0.4039 mL||2.0194 mL||4.0389 mL|
|10 mM||0.2019 mL||1.0097 mL||2.0194 mL|
CAS No.: 1217022-63-3 Get quote