Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

PTC-209

HY-15888

(PTC209; PTC 209)

PTC-209

PTC-209 Chemical Structure

PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $150 In-stock
50 mg $450 In-stock
100 mg $650 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €119 In-stock
5 mg €108 In-stock
10 mg €147 In-stock
50 mg €441 In-stock
100 mg €637 In-stock
200 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: PTC-209
Cat. No.: HY-15888

PTC-209 Data Sheet

  • View current batch:

    Purity: 99.98%

  • Pdf Version Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Customer View

Related Compound Libraries

Biological Activity of PTC-209

PTC-209 is a specific inhibitor  for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays.
IC50 value: 0.5 uM [1]
Target: BMI-1
PTC-209 inhibited not only the UTR-mediated reporter expression but also endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 caused no inhibition of cell growth or viability in HEK293 human embryonic kidney cells after overnight treatment and had limited effects on cell proliferation in HT1080 cells after a 48-h treatment. PTC-209 selectively reduced global ubiquitinated histone H2A (uH2A) but not total H2A and RING1A levels indicating its ability to specifically reduce PRC1 activity. Compound PTC-209 preferentially inhibits the proliferation of  human lymphoma U937 and HT1080 tumor cells, whereas it is lesseffective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells.

Chemical Information

M.Wt 495.19 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C17H13Br2N5OS
CAS No 315704-66-6
Solvent & Solubility

DMSO: 42 mg/ml

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.0194 mL 10.0971 mL 20.1943 mL
5 mM 0.4039 mL 2.0194 mL 4.0389 mL
10 mM 0.2019 mL 1.0097 mL 2.0194 mL

References on PTC-209

Other Forms

Inhibitor Kit