Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His)

Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Jagged-1/JAG1 Protein, Human (1013a.a, HEK293, His) is 1013 a.a., with molecular weight of 120-140 kDa.

The Jagged-1 (JAG1) protein functions as a ligand for multiple Notch receptors, playing a crucial role in mediating Notch signaling, as evidenced by its interactions with NOTCH1, NOTCH2, and NOTCH3. Its involvement in cell-fate decisions during hematopoiesis suggests a regulatory role in blood cell development. JAG1 is implicated in various stages of mammalian cardiovascular development and has been associated with both early and late phases of this process. Additionally, it inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis in vitro. Notably, the interaction between JAG1 and NOTCH1 is calcium ion-dependent, highlighting the complexity of its regulatory mechanisms in cellular processes.

Human

HEK293

C-His

P78504-1 (Q34-S1046)

/

120-140 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.