P371 Protein, Human (Sf9, FLAG)

The P371 protein is critical in cellular processes and mediates vitamin K-dependent carboxylation of glutamate residues to form calcium-binding γ-carboxyglutamic acid (Gla) residues. At the same time, it converts the reduced hydroquinone form of vitamin K into vitamin K epoxide. P371 Protein, Human (Sf9, FLAG) is the recombinant human-derived P371 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of P371 Protein, Human (Sf9, FLAG) is 758 a.a., .

P371 Protein plays a crucial role in cellular processes by mediating the vitamin K-dependent carboxylation of glutamate residues, converting them into calcium-binding gamma-carboxyglutamate (Gla) residues while simultaneously transforming the reduced hydroquinone form of vitamin K into vitamin K epoxide. The protein's catalytic activity extends to the gamma-carboxylation of diverse proteins, including blood coagulation factors (F2, F7, F9, and F10), osteocalcin (BGLAP), and matrix Gla protein (MGP). This enzymatic function is pivotal for the post-translational modification of these proteins, ensuring their proper biological activity, particularly in blood coagulation and bone metabolism. P371's role as a mediator in vitamin K-dependent processes highlights its significance in maintaining the functionality of various proteins critical to physiological homeostasis.

Human

Sf9 insect cells

C-Flag

P38435 (M1-F758)

2677

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.