PCK2 Protein, Human (sf9, His-GST)

The PCK2 protein serves as a key enzyme in cellular metabolism by catalyzing the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), representing the rate-limiting step in the metabolic pathway responsible for generating glucose from lactate and other precursors derived from the citric acid cycle. This enzymatic activity plays a critical role in gluconeogenesis, a fundamental process that contributes to the maintenance of glucose homeostasis in the body. Through the transformation of OAA to PEP, PCK2 facilitates the synthesis of glucose, a vital energy source, and orchestrates a crucial step in the intricate interplay of metabolic pathways involved in cellular energy balance and glucose production. PCK2 Protein, Human (sf9, His-GST) is the recombinant human-derived PCK2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of PCK2 Protein, Human (sf9, His-GST) is 608 a.a., with molecular weight of ~94.9 kDa.

The PCK2 protein serves as a key enzyme in cellular metabolism by catalyzing the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), representing the rate-limiting step in the metabolic pathway responsible for generating glucose from lactate and other precursors derived from the citric acid cycle. This enzymatic activity plays a critical role in gluconeogenesis, a fundamental process that contributes to the maintenance of glucose homeostasis in the body. Through the transformation of OAA to PEP, PCK2 facilitates the synthesis of glucose, a vital energy source, and orchestrates a crucial step in the intricate interplay of metabolic pathways involved in cellular energy balance and glucose production.

Human

Sf9 insect cells

C-His;N-GST

Q16822 (L33-M640)

5106  [NCBI]

Approximately 94.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.