PGLYRP4/PGRP-I beta Protein, Human (HEK293, His)

PGLYRP4/PGRP-I beta protein is a model receptor that binds to the cell wall peptide peptidoglycan (PGN) in Gram-positive bacteria and exerts bactericidal activity by interfering with peptidoglycan biosynthesis. Its antimicrobial properties extend to Gram-negative bacteria, although it also binds to them. PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) is the recombinant human-derived PGLYRP4/PGRP-I beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) is 356 a.a., with molecular weight of ~40.2 KDa.

PGLYRP4/PGRP-I beta Protein, a pattern receptor, exhibits binding affinity to murein peptidoglycans (PGN) found in Gram-positive bacteria, showcasing bactericidal activity against this bacterial group. Its antimicrobial properties may be attributed to its interference with peptidoglycan biosynthesis, leading to the killing of Gram-positive bacteria. Additionally, PGLYRP4/PGRP-I beta demonstrates bacteriostatic activity against Gram-negative bacteria, despite also binding to this bacterial class. As part of innate immunity, this protein plays a crucial role in recognizing and responding to bacterial pathogens. It forms homodimers connected by disulfide bonds and can heterodimerize with PGLYRP3, further expanding its functional repertoire in host defense mechanisms.

Human

HEK293

C-His

Q96LB8-1 (D18-H373)

57115  [NCBI]

DSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH

Approximately 50-72 kDa due to the glycosylation

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCL, 100 mM NaCl, pH 8.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.