Syntaxin-BP1 Protein, Human (sf9, His-GST)

Syntaxin-BP1 Protein crucially regulates synaptic vesicle docking and fusion, binding GTP-binding proteins and ensuring efficient neurotransmission. It interacts with syntaxin in a 1:1 ratio, displaying specificity for syntaxins 1, 2, and 3 (excluding syntaxin 4). Syntaxin-BP1 actively engages in neurotransmitter release by interacting with STX1A, facilitating SNARE complex assembly, recruiting SNAP25 and VAMP2, and mediating neurotransmitter release. It also controls alpha-synuclein/SNCA aggregation and promotes RAB3A dissociation from vesicle membranes, highlighting its multifaceted role in synaptic processes and diverse molecular interactions. Syntaxin-BP1 Protein, Human (sf9, His-GST) is the recombinant human-derived Syntaxin-BP1 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of Syntaxin-BP1 Protein, Human (sf9, His-GST) is 594 a.a., with molecular weight of ~80 kDa.

Syntaxin-BP1 Protein plays a crucial role in the regulation of synaptic vesicle docking and fusion by interacting with GTP-binding proteins, and it is essential for efficient neurotransmission. This protein binds to syntaxin, a key component of the synaptic vesicle fusion machinery, likely in a 1:1 ratio, and demonstrates interaction specificity with syntaxins 1, 2, and 3, excluding syntaxin 4. Syntaxin-BP1 is actively involved in neurotransmitter release from neurons by interacting with SNARE complex component STX1A, facilitating the assembly of the SNARE complex at synaptic membranes. This interaction recruits SNARE complex components SNAP25 and VAMP2, contributing to the mediation of neurotransmitter release. Moreover, Syntaxin-BP1 engages in interactions with alpha-synuclein/SNCA, exerting control over SNCA self-replicating aggregation. Additionally, its interaction with RAB3A promotes RAB3A dissociation from the vesicle membrane, further emphasizing its multifaceted role in synaptic processes. The protein also interacts with CABP5, highlighting its involvement in diverse molecular interactions within the neuronal environment.

Human

Sf9 insect cells

N-His;N-GST

P61764 (M1-S594)

6812  [NCBI]

Approximately 80 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.