TRPV2 Protein, Rat (Cell-Free, His)

The TRPV2 protein is a calcium-permeable nonselective cation channel with outward rectification and may be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/tau activator. TRPV2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived TRPV2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TRPV2 Protein, Rat (Cell-Free, His) is 761 a.a., with molecular weight of 88.2 kDa.

TRPV2, a calcium-permeable, non-selective cation channel, exhibits outward rectification and is potentially regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/head activator. This channel may play a role in transducing physical stimuli in mast cells. It is activated by temperatures exceeding 52 degrees Celsius but remains unresponsive to vanilloids and acidic pH. TRPV2 is likely organized as a homotetramer and interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Additionally, TRPV2 engages in an interaction with SLC50A1, possibly within intracellular compartments, and this interaction is contingent on TRPV2 N-glycosylation. These molecular interactions suggest a multifaceted regulatory network governing TRPV2 function and responsiveness to various stimuli.

Rat

E. coli Cell-free

N-10*His

Q9WUD2 (M1-P761)

29465

MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP

88.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.