2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB 271046

SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity.

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SB 271046 Chemical Structure

SB 271046 Chemical Structure

CAS No. : 209481-20-9

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Description

SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1].

IC50 & Target[1]

5-HT6 Receptor

8.92-9.09 (pKi)

In Vitro

In functional studies on human 5-HT6 receptors SB 271046 competitively antagonized 5-HT-induced stimulation of adenylyl cyclase activity with a pA2 of 8.71[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB 271046 Related Antibodies
In Vivo

SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ⩽0.1 mg/kg p.o. and maximum effect at 4 h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50 of 0.16 μM) and brain concentrations of 0.01-0.04 μM at Cmax[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

451.99

Formula

C20H22ClN3O3S2
CAS No.
SMILES

O=S(NC1=CC=C(C(N2CCNCC2)=C1)OC)(C3=C(C)C4=C(C=CC(Cl)=C4)S3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB 271046 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 271046209481-20-9SB271046SB-2710465-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6 receptororally activeanticonvulsant activityInhibitorinhibitorinhibit

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