Search Result
Results for "
AMC
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
7-Amino-4-methylcoumarin belongs to a group of coumarins. 7-Amino-4-methylcoumarin can be isolated from an endophytic fungus Xylaria sp., has broad antimicrobial activity. 7-Amino-4-methylcoumarin is additionally commonly used as an important laser dye emitting in the blue region, as well as a fluorescent probe enabling analyses of glycoproteins’ monosaccharides and N-linked oligosaccharides. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively .
|
-
-
- HY-P2237
-
-
-
- HY-P1003
-
|
Fluorescent Dye
|
Others
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
-
- HY-P3363
-
|
Caspase
|
Cancer
|
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
-
- HY-143285
-
|
Fluorescent Dye
|
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
-
-
- HY-P1759
-
Z-FR-AMC
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
|
-
-
- HY-P2008
-
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
|
-
-
- HY-P10082
-
|
Caspase
|
Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
-
- HY-P4217
-
|
Cathepsin
|
Others
|
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
|
-
-
- HY-129867
-
Z-LLL-AMC
|
Proteasome
|
Others
|
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
|
-
-
- HY-134434
-
|
Cathepsin
|
Others
|
Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .
|
-
-
- HY-134961
-
Fluorogenic Proteasome Substrate; Z-ARR-AMC
|
Proteasome
|
Others
|
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
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-
-
- HY-P10060
-
-
-
- HY-P0019A
-
|
Fluorescent Dye
|
Others
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
-
- HY-P5976
-
Renin Substrate I
|
Renin
|
Others
|
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
|
-
-
- HY-P2176
-
Z-Leu-Arg-Gly-Gly-AMC
|
Biochemical Assay Reagents
|
Others
|
Z-LRGG-AMC (Z-Leu-Arg-Gly-Gly-AMC) is a fluorescent substrate that hydrolyzes and releases free fluorescent 7-amino-4-methylcoumarin (AMC). Detection wavelength of AMC: Ex/Em=360/460 nm .
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-
-
- HY-137844
-
Leu-AMC hydrochloride
|
Fluorescent Dye
|
Others
|
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
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-
-
- HY-P10142
-
|
Fluorescent Dye
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Others
|
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
|
-
-
- HY-P4547
-
AC-WEHD-AMC
|
Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
-
- HY-P4548
-
Boc-RVRR-AMC
|
Furin
|
Others
|
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
|
-
-
- HY-P4449
-
|
Caspase
|
Cancer
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
-
-
- HY-P4417A
-
|
Fluorescent Dye
|
Others
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
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-
-
- HY-P3110
-
|
Fluorescent Dye
|
Others
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
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-
-
- HY-D1652
-
|
Caspase
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Others
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Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
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-
-
- HY-P1759B
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Z-FR-AMC TFA
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
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-
-
- HY-P10147
-
|
Caspase
|
Cancer
|
Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
|
-
-
- HY-120659
-
|
Fluorescent Dye
|
Others
|
Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
|
-
-
- HY-142021
-
|
Parasite
|
Infection
|
Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .
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-
-
- HY-134435
-
|
Fluorescent Dye
|
Others
|
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
|
-
-
- HY-D1634
-
|
Cathepsin
|
Others
|
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
-
- HY-D1503
-
-
-
- HY-P10144
-
|
Fluorescent Dye
|
Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
-
-
- HY-D1705
-
|
Proteasome
|
Inflammation/Immunology
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
-
- HY-145983
-
|
FAP
|
Cancer
|
Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP .
|
-
-
- HY-W142117
-
|
Fluorescent Dye
|
Others
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
-
-
- HY-P3362
-
|
Fluorescent Dye
|
Others
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
-
- HY-P10162
-
|
Caspase
|
Cancer
|
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
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-
-
- HY-P4392
-
-
-
- HY-P4340
-
|
Cathepsin
|
Cancer
|
Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .
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-
-
- HY-137416
-
-
-
- HY-P1448
-
-
-
- HY-134432A
-
|
Ser/Thr Protease
|
Others
|
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 .
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-
-
- HY-134432B
-
|
Ser/Thr Protease
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Others
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
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-
-
- HY-P4126
-
|
Elastase
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Others
|
Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .
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-
-
- HY-P4369
-
-
-
- HY-128919
-
|
HDAC
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Others
|
Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs .
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-
-
- HY-P4359
-
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PIN1
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Others
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Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
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-
-
- HY-136542
-
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Others
|
Cancer
|
H-β-Ala-AMC TFA is a substrate for aminopeptidase.
|
-
-
- HY-P4344
-
|
MetAP
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Others
|
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
|
-
-
- HY-123053
-
Z-LLE-AMC
|
Proteasome
|
Others
|
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
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-
- HY-D1670
-
-
- HY-123051
-
-
- HY-P4338
-
|
PAI-1
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Others
|
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
|
-
- HY-137337
-
|
Fluorescent Dye
|
Others
|
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
|
-
- HY-P4348
-
|
Proteasome
|
Others
|
MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
|
-
- HY-P4362
-
|
Elastase
|
Others
|
Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase .
|
-
- HY-P4366
-
-
- HY-P4390
-
-
- HY-P2016
-
|
Proteasome
|
Others
|
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
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-
- HY-P1002
-
-
- HY-P4339
-
|
Fluorescent Dye
|
Others
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Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
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-
- HY-P4350
-
|
Elastase
|
Others
|
Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
|
-
- HY-P5280
-
|
Ser/Thr Protease
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Others
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
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-
- HY-P2462
-
|
HDAC
|
Others
|
Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
|
-
- HY-136865
-
|
Fluorescent Dye
|
Others
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-123052
-
-
- HY-138159
-
-
- HY-148073
-
-
- HY-P2065
-
|
Fluorescent Dye
|
Others
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-135172
-
|
Fluorescent Dye
|
Others
|
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
|
-
- HY-D1534
-
-
- HY-137784
-
|
Fluorescent Dye
|
Others
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-137834
-
|
Fluorescent Dye
|
Others
|
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .
|
-
- HY-P0019
-
-
- HY-P4346
-
|
Elastase
|
Others
|
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
|
-
- HY-155667
-
|
Others
|
Others
|
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-155667A
-
|
Cathepsin
|
Others
|
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-P3791
-
|
Fluorescent Dye
|
Others
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
-
- HY-P4399
-
|
Bacterial
ClpP
|
Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
-
- HY-P4388
-
|
SARS-CoV
|
Infection
|
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
|
-
- HY-P4326
-
|
Fluorescent Dye
|
Others
|
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-124855
-
|
Deubiquitinase
|
Cancer
|
STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay .
|
-
- HY-150504
-
|
Others
|
Inflammation/Immunology
|
ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM .
|
-
- HY-130082
-
|
ADC Cytotoxin
Microtubule/Tubulin
|
Cancer
|
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM .
|
-
- HY-120458
-
LCA hydroxyamide
|
Deubiquitinase
|
Cancer
|
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
|
-
- HY-151871
-
|
Dipeptidyl Peptidase
HIV
|
Infection
|
ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dyes/Probes
|
7-Amino-4-methylcoumarin belongs to a group of coumarins. 7-Amino-4-methylcoumarin can be isolated from an endophytic fungus Xylaria sp., has broad antimicrobial activity. 7-Amino-4-methylcoumarin is additionally commonly used as an important laser dye emitting in the blue region, as well as a fluorescent probe enabling analyses of glycoproteins’ monosaccharides and N-linked oligosaccharides. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively .
|
-
- HY-P1003
-
|
Chromogenic Substrates
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-P3363
-
|
Chromogenic Substrates
|
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
- HY-P0019A
-
|
Chromogenic Substrates
|
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
- HY-143285
-
|
Fluorescent Dyes/Probes
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
-
- HY-137844
-
Leu-AMC hydrochloride
|
Fluorescent Dyes/Probes
|
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .
|
-
- HY-P3110
-
|
Dyes
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-134435
-
|
Fluorescent Dyes/Probes
|
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
|
-
- HY-D1634
-
|
Chromogenic Substrates
|
Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM -1s -1. The high concentration of BZ-FVR-AMC inhibits the substrate .
|
-
- HY-D1503
-
-
- HY-D1705
-
|
Fluorescent Dyes/Probes
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-W142117
-
-
- HY-P3362
-
|
Fluorescent Dyes/Probes
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-P1448
-
-
- HY-134432B
-
|
Dyes
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-D1670
-
-
- HY-123051
-
-
- HY-P1002
-
-
- HY-136865
-
|
Fluorescent Dyes/Probes
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
-
- HY-138159
-
-
- HY-148073
-
-
- HY-P2065
-
|
Fluorescent Dyes/Probes
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-P0019
-
|
Chromogenic Substrates
|
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
|
-
- HY-P3791
-
|
Fluorescent Dyes/Probes
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P2237
-
-
- HY-P1003
-
|
Fluorescent Dye
|
Others
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-P3363
-
|
Caspase
|
Cancer
|
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
|
-
- HY-P1759
-
Z-FR-AMC
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
|
-
- HY-P2008
-
IEGR-AMC
|
Factor Xa
|
Cardiovascular Disease
|
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
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-
- HY-P10082
-
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Caspase
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Others
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Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
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-
- HY-P4217
-
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Cathepsin
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Others
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Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .
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-
- HY-129867
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Z-LLL-AMC
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Proteasome
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Others
|
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
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-
- HY-134434
-
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Cathepsin
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Others
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Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .
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-
- HY-134961
-
Fluorogenic Proteasome Substrate; Z-ARR-AMC
|
Proteasome
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Others
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Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .
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-
- HY-P10198
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-
- HY-P10060
-
-
- HY-P0019A
-
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Fluorescent Dye
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Others
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Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).
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-
- HY-P5976
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Renin Substrate I
|
Renin
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Others
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Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
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-
- HY-P2176
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Z-Leu-Arg-Gly-Gly-AMC
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Biochemical Assay Reagents
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Others
|
Z-LRGG-AMC (Z-Leu-Arg-Gly-Gly-AMC) is a fluorescent substrate that hydrolyzes and releases free fluorescent 7-amino-4-methylcoumarin (AMC). Detection wavelength of AMC: Ex/Em=360/460 nm .
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-
- HY-P4417
-
|
Peptides
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Others
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Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
- HY-136626
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Cbz-Ala-Ala-Asn-AMC
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Peptides
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Cancer
|
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .
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-
- HY-P10142
-
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Fluorescent Dye
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Others
|
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
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-
- HY-P4547
-
AC-WEHD-AMC
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Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
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-
- HY-P4548
-
Boc-RVRR-AMC
|
Furin
|
Others
|
Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin .
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-
- HY-P4449
-
|
Caspase
|
Cancer
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
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-
- HY-P4443
-
|
Peptides
|
Others
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Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .
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-
- HY-P4417A
-
|
Fluorescent Dye
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Others
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Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
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-
- HY-P4427
-
|
Peptides
|
Others
|
Z-VAN-AMC is a fluorogenic substrate. Z-VAN-AMC can be hydrolysed by a phytophagous mite of legumain-like activity .
|
-
- HY-P5202
-
|
Peptides
|
Others
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H-Gly-Gly-Arg-AMC is a fluorogenic peptidyl-AMC substrate containing C-terminal 7-amino-4-methylcoumarin (AMC). H-Gly-Gly-Arg-AMC is a suitable for monitoring continuous thrombin generation (TGT) .
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-
- HY-P3110
-
|
Fluorescent Dye
|
Others
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
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-
- HY-P1759B
-
Z-FR-AMC TFA
|
Cathepsin
|
Others
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes .
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-
- HY-P10147
-
|
Caspase
|
Cancer
|
Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
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-
- HY-P4349
-
|
Peptides
|
Others
|
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .
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-
- HY-P4323
-
|
Peptides
|
Others
|
Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
- HY-P4408
-
|
Peptides
|
Others
|
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
- HY-P4349A
-
|
Peptides
|
Others
|
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .
|
-
- HY-P10144
-
|
Fluorescent Dye
|
Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
-
- HY-W142117
-
|
Fluorescent Dye
|
Others
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
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-
- HY-P3362
-
|
Fluorescent Dye
|
Others
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-P10162
-
|
Caspase
|
Cancer
|
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
|
-
- HY-P4416
-
|
Peptides
|
Others
|
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P4419
-
|
Peptides
|
Others
|
Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
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-
- HY-P4342
-
-
- HY-P4345
-
-
- HY-P4392
-
-
- HY-P4340
-
|
Cathepsin
|
Cancer
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Arg-Arg-AMC is a highly selective substrate of Cathepsin B. Arg-Arg-AMC can be used to cathepsin B activity assay in cancer cells, while cathepsin B is assocaited with cell invasive and metastatic phenotype in numerous types of cancer .
|
-
- HY-137416
-
-
- HY-P4363
-
|
Peptides
|
Others
|
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .
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-
- HY-P4360
-
|
Peptides
|
Others
|
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .
|
-
- HY-P1448
-
-
- HY-P4367
-
|
Peptides
|
Others
|
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .
|
-
- HY-134432B
-
|
Ser/Thr Protease
|
Others
|
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 .
|
-
- HY-P4426
-
|
Peptides
|
Others
|
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
|
-
- HY-137811
-
Suc-Ala-Ala-Pro-Phe-AMC
|
Peptides
|
Others
|
Suc-AAPF-AMC is an α-chymotrypsin fluorogenic substrate for the quantitative determination of chymotrypsin activity .
|
- HY-P4209
-
|
Peptides
|
Others
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P4126
-
|
Elastase
|
Others
|
Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .
|
- HY-P4369
-
- HY-P4359
-
|
PIN1
|
Others
|
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .
|
- HY-P4344
-
|
MetAP
|
Others
|
Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
|
- HY-123053
-
Z-LLE-AMC
|
Proteasome
|
Others
|
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome
|
- HY-123051
-
- HY-P4338
-
|
PAI-1
|
Others
|
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
|
- HY-137337
-
|
Fluorescent Dye
|
Others
|
Suc-Ala-Ala-Phe-AMC is a fluorogenic chymotrypsin substrate, can be hydrolyzed by endopeptidase. Suc-Ala-Ala-Phe-AMC has been used in both in vivo assays of the acrosome reaction and in vitro enzyme assays .
|
- HY-137834A
-
|
Peptides
|
Others
|
Gly-Pro-AMC is a biological active peptide. (This is a fluorescent dipeptidylaminopeptidase IV substrate, Abs/Em=353/442 nm.)
|
- HY-P4209A
-
|
Peptides
|
Others
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
- HY-P4341
-
- HY-P4348
-
|
Proteasome
|
Others
|
MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal .
|
- HY-P4362
-
|
Elastase
|
Others
|
Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase .
|
- HY-P4426A
-
|
Peptides
|
Others
|
Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .
|
- HY-P4366
-
- HY-P4390
-
- HY-P2016
-
|
Proteasome
|
Others
|
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
|
- HY-P1002
-
- HY-P4339
-
|
Fluorescent Dye
|
Others
|
Ala-Phe-Lys-AMC is a fluorogenic substrate, which can be used for residual plasmin activity assay .
|
- HY-P4350
-
|
Elastase
|
Others
|
Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .
|
- HY-P4312
-
|
Peptides
|
Others
|
Boc-Leu-Lys-Arg-AMC is a fluorogenic substrate for the Kex2 endoprotease .
|
- HY-P5280
-
|
Ser/Thr Protease
|
Others
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
- HY-P2462
-
|
HDAC
|
Others
|
Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
|
- HY-P4319
-
|
Peptides
|
Others
|
Boc-Glu-Lys-Lys-AMC is a sensitive fluorogenic substrate for urokinase-activated plasmin .
|
- HY-136865
-
|
Fluorescent Dye
|
Others
|
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm) .
|
- HY-P4347
-
|
Peptides
|
Others
|
MeOSuc-Ala-Phe-Lys-AMC TFA is a peptide substrate of plasmin .
|
- HY-W719799
-
|
Peptides
|
Others
|
Suc-Ala-Leu-Pro-Phe-AMC is a PPIase fluorogenic substrate .
|
- HY-P2065
-
|
Fluorescent Dye
|
Others
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
- HY-135172
-
|
Fluorescent Dye
|
Others
|
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
|
- HY-P0019
-
- HY-P4428
-
|
Peptides
|
Others
|
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .
|
- HY-P4346
-
|
Elastase
|
Others
|
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .
|
- HY-P3791
-
|
Fluorescent Dye
|
Others
|
N-Succinyl-Ile-Ile-Trp-AMC is a peptide-based fluorescent substrate or probe for carboxypeptidase Y (CPY) .
|
- HY-P4399
-
|
Bacterial
ClpP
|
Others
|
Z-Gly-Gly-Leu-AMC is the substrate of ClpP1 and ClpP2, to detect the enzymatic activity in the presence of the activating peptide Z-Leu-Leu .
|
- HY-P4388
-
|
SARS-CoV
|
Infection
|
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL pro .
|
- HY-P5378
-
Cathepsin S substrate
|
Peptides
|
Others
|
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)
|
- HY-P4310
-
|
Peptides
|
Others
|
Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
|
- HY-P4331
-
|
Peptides
|
Others
|
Boc-Gln-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4314
-
|
Peptides
|
Others
|
Boc-Gly-Lys-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4332
-
|
Peptides
|
Others
|
Boc-Glu(OBzl)-Ala-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4333
-
|
Peptides
|
Others
|
Boc-Glu(OBzl)-Gly-Arg-AMC is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4425
-
|
Peptides
|
Others
|
Gly-Phe-AFC is a fluorescent substrate, which is a peptide sequence composed of glycine and phenylalanine, linked to the fluorescent group AFC .
|
- HY-P4326
-
|
Fluorescent Dye
|
Others
|
Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
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