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C1s

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (1) Biochemical Assay Reagents (2) Complement System (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (8)

10

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Riliprubart SAR 445088	Complement System	Inflammation/Immunology
Riliprubart (SAR445088) is an *anti-C1s* humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a ^[1].

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase ^[1].

C1S Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C1S Human Pre-designed siRNA Set A contains three designed siRNAs for C1S gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1S Human Pre-designed siRNA Set A C1S Human Pre-designed siRNA Set A

HY-W371164

C1s-IN-1

Complement System Inflammation/Immunology

C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a K_d of 9.8 μM ^[1].

Complement C1s-IN-1	Complement System	Inflammation/Immunology
Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier *C1s* inhibitor with an IC₅₀ value of 36 nM ^[1].

BCX 1470	Complement System	Inflammation/Immunology
BCX 1470 inhibits the esterolytic activity of factor D (IC₅₀=96 nM) and *C1s* (IC₅₀=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

BCX 1470 methanesulfonate	Complement System	Inflammation/Immunology
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC₅₀=96 nM) and *C1s* (IC₅₀=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

(S)-Sabutoclax (S)-BI-97C1	Bcl-2 Family	Cancer
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer ^[1].

O-Phthalimide-C1-S-C5-acid MFH	Biochemical Assay Reagents	Inflammation/Immunology
6-(N-Phthalimidoylmethylthio)hexanoic acid (MFH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-(N-Phthalimidoylmethylthio)hexanoic acid can be combined with carrier proteins and used in antigen design ^[1].

O-Phthalimide-C1-S-C1-acid MFA	Biochemical Assay Reagents	Inflammation/Immunology
2-(N-Phthalimidoylmethylthio)acetic acid (MFA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 2-(N-Phthalimidoylmethylthio)acetic acid can be combined with carrier proteins and used in antigen design ^[1].

Cat. No.	Product Name	Target	Research Area

2Abz-SLGRKIQIK(Dnp)-NH2	Peptides	Others
2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)

Cat. No.	Product Name	Target	Research Area

Riliprubart SAR 445088	Complement System	Inflammation/Immunology
Riliprubart (SAR445088) is an *anti-C1s* humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a ^[1].

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase ^[1].

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	C1s/Complement component C1s Protein, Human (HEK293, His) Complement C1s subcomponent; C1 esterase	Human	HEK293
	C1s/Complement component C1s, a serine protease and B chain, forms C1 with C1q and C1r, initiating the classical complement pathway. Activated by C1r, C1s then activates downstream components C2 and C4, crucially driving the complement system cascade. C1s/Complement component C1s Protein, Human (HEK293, His) is the recombinant human-derived C1s/Complement component C1s protein, expressed by HEK293, with C-His labeled tag. The total length of C1s/Complement component C1s Protein, Human (HEK293, His) is 673 a.a., with molecular weight of 55-60 kDa (light chain), 32-35 kDa (heavy chain).

	C1s-A subcomponent Protein, Mouse (HEK293, His) Complement C1s-A subcomponent; C1 esterase; C1sa; C1s	Mouse	HEK293
	C1s-A subcomponent protein, a serine protease, is pivotal in the classical complement system pathway. Partnering with C1q and C1r, it forms C1, initiating complement activation. Activated by C1r, C1s can subsequently trigger downstream components C2 and C4, influencing the complement system cascade. C1s-A subcomponent Protein, Mouse (HEK293, His) is the recombinant mouse-derived C1s-A subcomponent protein, expressed by HEK293, with C-His labeled tag. The total length of C1s-A subcomponent Protein, Mouse (HEK293, His) is 673 a.a., with molecular weight of ~76.6 kDa.

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