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Results for "

Clozapine

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14539
    Clozapine
    3 Publications Verification

    HF 1854

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    <em>Clozapine</em>
  • HY-17366
    Clozapine N-oxide
    Maximum Cited Publications
    67 Publications Verification

    		 mAChR Dopamine Receptor Drug Metabolite Neurological Disease
    Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
    <em>Clozapine</em> N-oxide
  • HY-17366A
    Clozapine N-oxide dihydrochloride
    Maximum Cited Publications
    67 Publications Verification

    		 mAChR Dopamine Receptor Drug Metabolite Neurological Disease
    Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
    <em>Clozapine</em> N-oxide dihydrochloride
  • HY-14539S
    Clozapine-d8

    HF 1854-d8

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].
    <em>Clozapine</em>-d8
  • HY-14539S2
    Clozapine-d4

    HF 1854-d4

    		 Isotope-Labeled Compounds Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].
    <em>Clozapine</em>-d4
  • HY-14539R
    Clozapine (Standard)

    HF 1854 (Standard)

    		 Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor Neurological Disease
    Clozapine (Standard) is the analytical standard of Clozapine. This product is intended for research and analytical applications. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
    <em>Clozapine</em> (Standard)
  • HY-142592S
    Clozapine EP impurity D-d8

    		Drug Metabolite Isotope-Labeled Compounds Others
    Clozapine EP impurity D-d8 is the deuterium labeled Clozapine EP impurity D[1].
    <em>Clozapine</em> EP impurity D-d8
  • HY-131891
    JHU37152

    		mAChR Neurological Disease
    JHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [ 3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .
    JHU37152
  • HY-131881
    JHU37160

    		mAChR Neurological Disease
    JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [ 3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .
    JHU37160
  • HY-117083
    Clothiapine

    		5-HT Receptor Neurological Disease
    Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .
    Clothiapine
  • HY-W127671
    Tetramethylammonium perchlorate

    		Biochemical Assay Reagents Others
    Tetramethylammonium perchlorate is used as an intermediate in organic and chemical synthesis. It is used as mobile phase in HPLC analysis and quantification of olanzapine, clozapine and N-desmethylclozapine. It acts as a supporting electrolyte in the electrochemical reduction of 1-bromodecane, 1-iodododecane, 2-iodooctane, and 2-bromooctane on a mercury cathode.
    Tetramethylammonium perchlorate
  • HY-42110
    Deschloroclozapine
    30+ Cited Publications

    		 mAChR Neurological Disease
    Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [ 11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .
    Deschloroclozapine
  • HY-42110A
    Deschloroclozapine dihydrochloride
    30+ Cited Publications

    		 mAChR Neurological Disease
    Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [ 11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .
    Deschloroclozapine dihydrochloride
  • HY-G0021
    N-Desmethylclozapine

    NorClozapine; DesmethylClozapine; NormethylClozapine

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .
    N-Desmethylclozapine
  • HY-G0021S
    N-Desmethylclozapine-d8

    NorClozapine-d8; DesmethylClozapine-d8; NormethylClozapine-d8

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
    N-Desmethylclozapine-d8
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride

    NorClozapine-d8 hydrochloride; DesmethylClozapine-d8 hydrochloride; NormethylClozapine-d8 hydrochloride

    		 mAChR Opioid Receptor Drug Metabolite Virus Protease Infection
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
    N-Desmethylclozapine-d8 hydrochloride

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