Search Result

Results for "

DDR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) ATM/ATR (5) Bcr-Abl (2) c-Kit (4) c-Met/HGFR (2) c-Myc (1) Casein Kinase (1) CDK (1) Discoidin Domain Receptor (22) Endogenous Metabolite (1) Ephrin Receptor (1) FGFR (1) FLT3 (4) Histone Methyltransferase (1) JAK (1) JNK (1) mTOR (2) PDGFR (2) PI3K (2) PROTACs (1) Raf (1) RET (1) ROS Kinase (2) Small Interfering RNA (siRNA) (6) Trk Receptor (2) VEGFR (3)
By Research Areas:	Cancer (27) Inflammation/Immunology (8) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W018931

DDR Inhibitor	Discoidin Domain Receptor	Cancer
DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC₅₀ of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

HY-112545

DDR2-IN-1 1 Publications Verification	Discoidin Domain Receptor	Metabolic Disease
DDR2-IN-1 is potent *DDR2* inhibitor with an IC₅₀ of 26 nM. DDR2-IN-1, compound 129, can be used for osteoarthritis research .

HY-133669

DDR1-IN-5	Discoidin Domain Receptor	Cancer
DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC₅₀ of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC₅₀ of 4.1 nM. DDR1-IN-5 has anti-cancer activity . DDR1-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133670

DDR1-IN-6	Discoidin Domain Receptor	Cancer
DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC₅₀ of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC₅₀ of 9.7 nM. DDR1-IN-6 has anti-cancer activity . DDR1-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162102

DDR1-IN-8	Discoidin Domain Receptor	Cancer
DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC₅₀ values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity .

HY-156552

DDR1/2 inhibitor-2	Discoidin Domain Receptor	Inflammation/Immunology Cancer
DDR1/2 inhibitor-2 (Example 31) is a *DDR1/DDR2* inhibitor, with IC₅₀ values less than 100 nM. DDR1/2 inhibitor-2 can be used for research of cancer and fibrotic diseases .

HY-114173

DDR1-IN-4	Discoidin Domain Receptor	Inflammation/Immunology
DDR1-IN-4 (Compound 2.45) is a selective and potent Discoidin Domain Receptor 1 (DDR1) autophosphorylation inhibitor, with IC₅₀ values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively .

HY-13979

DDR1-IN-1 3 Publications Verification	Discoidin Domain Receptor	Cancer
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-13979A

DDR1-IN-1 dihydrochloride	Discoidin Domain Receptor	Cancer
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-100695

DDR-TRK-1

Discoidin Domain Receptor Cancer

DDR-TRK-1 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC₅₀ value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

DDR-TRK-1	Discoidin Domain Receptor	Cancer
DDR-TRK-1 is a selective Discoidin Domain Receptor 1 *(DDR1)* inhibitor, with an IC₅₀ value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

HY-U00444

7rh 3 Publications Verification DDR1-IN-2	Discoidin Domain Receptor	Inflammation/Immunology
7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC₅₀ of 13.1 nM, and also less potently inhibits DDR2, with an IC₅₀ of 203 nM. 7rh is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS03620

DDR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DDR1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDR1 Human Pre-designed siRNA Set A DDR1 Human Pre-designed siRNA Set A

HY-RS03621

Ddr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr1 Mouse Pre-designed siRNA Set A Ddr1 Mouse Pre-designed siRNA Set A

HY-RS03622

Ddr1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr1 Rat Pre-designed siRNA Set A Ddr1 Rat Pre-designed siRNA Set A

HY-RS03623

DDR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DDR2 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDR2 Human Pre-designed siRNA Set A DDR2 Human Pre-designed siRNA Set A

HY-RS03624

Ddr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr2 Mouse Pre-designed siRNA Set A Ddr2 Mouse Pre-designed siRNA Set A

HY-RS03625

Ddr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr2 Rat Pre-designed siRNA Set A Ddr2 Rat Pre-designed siRNA Set A

HY-114311

*FGFR1/DDR2 inhibitor 1*	FGFR Discoidin Domain Receptor	Cancer
FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC₅₀ values of 31.1 nM and 3.2 nM, respectively. Antitumor activity .

HY-120084

BTX161	Casein Kinase	Cancer
BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2 .

HY-135401

VU6015929 1 Publications Verification	Discoidin Domain Receptor	Inflammation/Immunology
VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC₅₀s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced *DDR1* activation and collagen-IV production .

HY-P1790

Axltide

JAK Metabolic Disease

Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

Axltide	JAK	Metabolic Disease
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

HY-16961

Sitravatinib 2 Publications Verification MGCD516; MG-516	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-16961A

Sitravatinib malate MGCD516 malate; MG-516 malate	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-15514A

Merestinib dihydrochloride 4 Publications Verification LY2801653 dihydrochloride	c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor	Cancer
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM) .

HY-15514

Merestinib 4 Publications Verification LY2801653	c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor	Cancer
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM) .

HY-113064

Selenocystine	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-149952

ATR-IN-23	ATM/ATR	Cancer
ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC₅₀ of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers .

HY-101034

CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155	Bcr-Abl c-Kit Apoptosis PDGFR Discoidin Domain Receptor	Cancer
CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC₅₀s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC₅₀=81 nM), CSF1R (IC₅₀=227 nM), DDR1 (IC₅₀=116 nM), DDR2 (IC₅₀=325 nM), LCK (IC₅₀=12 nM) and PDGFRβ (IC₅₀=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis .

HY-162384

EPIC-0628	Histone Methyltransferase	Cancer
EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency .

HY-150552

JNK3 inhibitor-2	JNK Discoidin Domain Receptor	Inflammation/Immunology Cancer
JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC₅₀ values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition .

HY-160689

GW694590A UNC10112731	c-Myc c-Kit Discoidin Domain Receptor PDGFR	Others
GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting *DDR2, KIT* and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene .

HY-144685

ATM Inhibitor-2

ATM/ATR Cancer

ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC₅₀ of <1 nM .

ATM Inhibitor-2	ATM/ATR	Cancer
ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC₅₀ of <1 nM .

HY-144686

ATM Inhibitor-3	ATM/ATR PI3K mTOR	Cancer
ATM Inhibitor-3 (compound 34) is a potent and selective ATM inhibitor, with an IC₅₀ of 0.71 nM. ATM Inhibitor-3 shows inhibition of PI3K kinases family. ATM Inhibitor-3 exhibits favorable metabolic stability .

HY-144687

ATM Inhibitor-4	ATM/ATR PI3K mTOR	Cancer
ATM Inhibitor-4 (compound 39) is a potent and selective ATM inhibitor, with an IC₅₀ of 0.32 nM. ATM Inhibitor-4 shows stronger inhibition of PI3K kinases family. ATM Inhibitor-4 shows a full inhibition of mTOR at 1 μM. ATM Inhibitor-4 exhibits favorable metabolic stability .

HY-114169

WRG-28	Discoidin Domain Receptor	Inflammation/Immunology Cancer
WRG-28 is a selective, extracellularly acting *DDR2* allosteric inhibitor, with an IC₅₀ of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice .

HY-144435

ATR-IN-11	ATM/ATR	Cancer
ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS). ATR-IN-11 is a promising lead compound for subsequent agent discovery targeting ATR kinase. ATR-IN-11 has the potential for the research of cancer disease .

HY-139039

BSJ-4-116	PROTACs CDK	Cancer
BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC₅₀ of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162) .

HY-14979A

ML786 dihydrochloride	Raf Bcr-Abl Discoidin Domain Receptor VEGFR RET Ephrin Receptor	Cancer
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC₅₀s of 2.1, 4.2, and 2.5 nM for ^V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, *DDR2, EPHA2, KDR, and RET* (IC₅₀=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers .

HY-115531

UNC-2170	Others	Cancer
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC₅₀=29 µM; K_d=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) .

Axltide	JAK	Metabolic Disease
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

Selenocystine	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

Selenocystine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

Species:	Human (6) Rhesus Macaque (2) Rat (4) Mouse (6)
Tag:	His (12) GST (4) Fc (5)
Source:	HEK293 (14) Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P75299

	DDR1 Protein, Rat (HEK293, His) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Rat	HEK293
	The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Rat (HEK293, His) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR1 Protein, Rat (HEK293, His) is 413 a.a., with molecular weight of 50-58 kDa.

HY-P75302

	DDR1 Protein, Mouse (HEK293, His) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Mouse	HEK293
	The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR1 Protein, Mouse (HEK293, His) is 414 a.a., with molecular weight of 50-60 kDa.

HY-P75305

	DDR1 Protein, Human (HEK293, His) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Human	HEK293
	The DDR1 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that tightly regulates cell attachment and affects extracellular matrix processes. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC, activating MAP kinase. DDR1 Protein, Human (HEK293, His) is the recombinant human-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR1 Protein, Human (HEK293, His) is 398 a.a., with molecular weight of 55-70 kDa.

HY-P75300

	DDR1 Protein, Rat (HEK293, hFc) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Rat	HEK293
	The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR1 Protein, Rat (HEK293, hFc) is 413 a.a., with molecular weight of ~71 kDa.

HY-P75303

	DDR1 Protein, Mouse (HEK293, Fc) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Mouse	HEK293
	DDR1 Protein, a fibrillar collagen receptor, orchestrates critical cellular processes, including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates a signaling cascade involving SRC and MAP kinases, contributing to matrix remodeling through MMP up-regulation, facilitating cell migration, wound healing, and tumor invasion. DDR1 also aids arterial wound healing, phosphorylates PTPN11, and is vital for blastocyst implantation, mammary gland differentiation, lactation, and ear morphology maintenance. Its multifunctional role underscores DDR1's significance in governing diverse physiological processes. DDR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived DDR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of DDR1 Protein, Mouse (HEK293, Fc) is 414 a.a., with molecular weight of 80-90 kDa.

HY-P75301

	DDR1 Protein, Mouse (sf9, His-GST) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Mouse	Sf9 insect cells
	DDR1 Protein, a fibrillar collagen receptor, orchestrates critical cellular processes, including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates a signaling cascade involving SRC and MAP kinases, contributing to matrix remodeling through MMP up-regulation, facilitating cell migration, wound healing, and tumor invasion. DDR1 also aids arterial wound healing, phosphorylates PTPN11, and is vital for blastocyst implantation, mammary gland differentiation, lactation, and ear morphology maintenance. Its multifunctional role underscores DDR1's significance in governing diverse physiological processes. DDR1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived DDR1 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of DDR1 Protein, Mouse (sf9, His-GST) is 431 a.a., with molecular weight of ~68 kDa.

HY-P75304

	DDR1 Protein, Human (sf9, His-GST) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Human	Sf9 insect cells
	The DDR1 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that tightly regulates cell attachment and affects extracellular matrix processes. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC, activating MAP kinase. DDR1 Protein, Human (sf9, His-GST) is the recombinant human-derived DDR1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DDR1 Protein, Human (sf9, His-GST) is 470 a.a., with molecular weight of ~80 kDa.

HY-P72673

	DDR2 Protein, Mouse (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Mouse	HEK293
	The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is crucial for bone development. It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2. DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DDR2 Protein, Mouse (HEK293, His) is 376 a.a., with molecular weight of 60-75 kDa.

HY-P75297

	DDR2 Protein, Rat (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rat	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rat (HEK293, His) is the recombinant rat-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75298

	DDR2 Protein, Rat (HEK293, hFc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rat	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76868

	DDR2 Protein, Human (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (HEK293, Fc) is the recombinant human-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Human (HEK293, Fc) is 399 a.a., with molecular weight of ~87 kDa.

HY-P76869

	DDR2 Protein, Human (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (HEK293, His) is the recombinant human-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR2 Protein, Human (HEK293, His) is 399 a.a., with molecular weight of ~54 kDa.

HY-P702713

DDR2 Protein, Human (sf9, GST)

Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10
Human Sf9 insect cells

HY-P75702

	DDR2 Protein, Rhesus Macaque (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rhesus Macaque	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75703

	DDR2 Protein, Rhesus Macaque (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rhesus Macaque	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76867

	DDR2 Protein, Human (sf9, His-GST) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	Sf9 insect cells
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (sf9, His-GST) is the recombinant human-derived DDR2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DDR2 Protein, Human (sf9, His-GST) is 434 a.a., with molecular weight of ~77 kDa.

HY-P77639

DDR1 Protein, Mouse (HEK293, C-His)

HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; DDR1; CD167; EDDR1; PTK3; CD167a; DDR; EC 2.7.10; EC 2.7.10.1; ENTRK4
Mouse HEK293

HY-P700707

	DR3/TNFRSF25 Protein, Mouse (HEK293, His) APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; TNFRSF25; LARD; TR3; TRAMP; WSL-LR	Mouse	HEK293
	The DR3/TNFRSF25 protein displays defects in conserved residues critical for propagation feature annotation. This defect in DR3/TNFRSF25 prevents the propagation of specific functional features associated with this protein. DR3/TNFRSF25 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DR3/TNFRSF25 protein, expressed by HEK293 , with C-His labeled tag. The total length of DR3/TNFRSF25 Protein, Mouse (HEK293, His) is 166 a.a., with molecular weight of 35-48 kDa.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks