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Results for "

FTY720

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

3

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12005
    Fingolimod hydrochloride
    Maximum Cited Publications
    27 Publications Verification

    FTY720

    		 LPL Receptor PAK Inflammation/Immunology Cancer
    Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator .
    Fingolimod hydrochloride
  • HY-15382
    FTY720 (S)-Phosphate
    1 Publications Verification

    (S)-FTY720P; (S)-FTY720 phosphate

    		 LPL Receptor Inflammation/Immunology
    FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
    <em>FTY720</em> (S)-Phosphate
  • HY-15381
    Fingolimod phosphate

    FTY720 phosphate

    		 LPL Receptor Infection Neurological Disease Inflammation/Immunology
    Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases .
    Fingolimod phosphate
  • HY-11063
    Fingolimod
    Maximum Cited Publications
    27 Publications Verification

    FTY720 free base

    		 LPL Receptor PAK Inflammation/Immunology Cancer
    Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .
    Fingolimod
  • HY-15381S
    Fingolimod phosphate-d4

    FTY720 phosphate-d4

    		 LPL Receptor Isotope-Labeled Compounds Others
    Fingolimod phosphate-d4 is deuterium labeled FTY720 Phosphate.
    Fingolimod phosphate-d4
  • HY-12005R
    Fingolimod hydrochloride (Standard)

    FTY720 (Standard)

    		 LPL Receptor PAK Inflammation/Immunology Cancer
    Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator .
    Fingolimod hydrochloride (Standard)
  • HY-11063S
    Fingolimod-d4

    FTY720 free based-d4

    		 LPL Receptor PAK Inflammation/Immunology Cancer
    Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].
    Fingolimod-d4
  • HY-11063S1
    Fingolimod-d4 hydrochloride

    FTY720-d4

    		 LPL Receptor PAK Inflammation/Immunology Cancer
    Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].
    Fingolimod-d4 hydrochloride
  • HY-15382A
    (S)-FTY720-phosphonate

    		LPL Receptor Inflammation/Immunology
    FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
    (S)-<em>FTY720</em>-phosphonate
  • HY-116088
    W123

    		LPL Receptor Inflammation/Immunology
    W123, a FTY720 analog, is a competitive sphingosine 1-phosphate type 1 (S1P1) receptor antagonist. W123 is measured by GTPγS activation, MAPK recruitment, cell migration, and ligand-induced receptor internalization .
    W123
  • HY-123794
    MP07-66

    		Phosphatase Cancer
    MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation .
    MP07-66
  • HY-114061
    (R)-FTY 720P

    		Others Others
    (R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382) .
    (R)-<em>FTY 720</em>P
  • HY-117720
    OSU-2S

    		PKC Apoptosis Cancer
    OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity .
    OSU-2S

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