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Results for "

GLI1-IN-1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13282
    GANT 58
    5+ Cited Publications

    NSC 75503

    		 Gli Cancer
    GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM .
    GANT 58
  • HY-N2112
    Glaucocalyxin A
    2 Publications Verification

    		 PI3K Akt Apoptosis Cancer
    Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .
    Glaucocalyxin A
  • HY-122590
    Glabrescione B

    		Gli Cancer
    Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells .
    Glabrescione B
  • HY-161459
    GLI1-IN-1

    		Apoptosis Hedgehog Gli Cancer
    GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway .
    <em>GLI1-IN-1</em>
  • HY-N8270
    Physalin H

    		Hedgehog Endogenous Metabolite Cancer
    Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively .
    Physalin H
  • HY-162273
    Antibacterial agent 189

    		Bacterial Smo Gli Infection Cancer
    Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .
    Antibacterial agent 189

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