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Results for "

Gly-6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (4) Autophagy (4) Bcl-2 Family (1) Caspase (1) DGK (1) IGF-1R (1) JAK (1) Mitochondrial Metabolism (1) Mitophagy (2) mTOR (1) Parasite (1) PDI (1) Phosphatase (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (9)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (6)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W107464

G6PDi-1	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive **glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀** of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-123962

G6PD activator AG1 1 Publications Verification	Others	Metabolic Disease
G6PD activator AG1 is a potent and selective **glucose-6-phosphate dehydrogenase (G6PD) activator with an EC₅₀** of 3 µΜ . G6PD activator AG1 reduces hemolysis of human erythrocytes .

HY-RS05194

G6PD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PD Human Pre-designed siRNA Set A contains three designed siRNAs for G6PD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PD Human Pre-designed siRNA Set A G6PD Human Pre-designed siRNA Set A

HY-RS05195

G6PR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PR Human Pre-designed siRNA Set A contains three designed siRNAs for G6PR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PR Human Pre-designed siRNA Set A G6PR Human Pre-designed siRNA Set A

HY-RS05191

G6PC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PC1 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PC1 Human Pre-designed siRNA Set A G6PC1 Human Pre-designed siRNA Set A

HY-RS05192

G6PC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PC2 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PC2 Human Pre-designed siRNA Set A G6PC2 Human Pre-designed siRNA Set A

HY-RS05193

G6PC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PC3 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PC3 Human Pre-designed siRNA Set A G6PC3 Human Pre-designed siRNA Set A

HY-RS10633

PLA2G6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G6 Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G6 Human Pre-designed siRNA Set A PLA2G6 Human Pre-designed siRNA Set A

HY-RS07898

LY6G6C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6C Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6C Human Pre-designed siRNA Set A LY6G6C Human Pre-designed siRNA Set A

HY-RS07899

LY6G6D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6D Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6D Human Pre-designed siRNA Set A LY6G6D Human Pre-designed siRNA Set A

HY-RS07900

LY6G6F Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6F Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6F Human Pre-designed siRNA Set A LY6G6F Human Pre-designed siRNA Set A

HY-18293

NSC 33994

JAK Autophagy Cancer

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC₅₀ of 60 nM .
HY-16443

S-4048

Others Metabolic Disease

S-4048 is a Glucose-6-phosphatase (G6Pase) inhibitor with an IC₅₀ value of 9.4 nM for rat microsomes.

NSC 33994	JAK Autophagy	Cancer
NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC₅₀ of 60 nM .

S-4048	Others	Metabolic Disease
S-4048 is a **Glucose-6-phosphatase (G6Pase) inhibitor with an IC₅₀** value of 9.4 nM for rat microsomes.

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	Others	Others
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active Foxo1 inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .

HY-106328

Fluasterone	Others	Metabolic Disease Inflammation/Immunology Cancer
Fluasterone is a potent *G6PD* inhibitor with a K_i of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active .

HY-122949

Momordicine I	DGK	Metabolic Disease
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .

HY-115449

Chromeceptin 94G6	IGF-1R Akt mTOR	Cancer
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .

HY-N0120A

Polydatin Maximum Cited Publications 10 Publications Verification Piceid	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-138877A

Phosphoglycolic acid lithium	Phosphatase	Cancer
Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid increases basal and fMLF-induced levels of G6P in intact neutrophils. Phosphoglycolic acid thereby increases upstream intermediates in neutrophils, thereby amplifying the respiratory oxidative burst .

HY-N0120AR

Polydatin (Standard) Maximum Cited Publications 10 Publications Verification Piceid (Standard)	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-W010342

6-Aminonicotinamide 4 Publications Verification	Others	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme **glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i**=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells .

HY-16438

RRx-001 5+ Cited Publications	Apoptosis Parasite	Infection Inflammation/Immunology Cancer
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α . RRx-001 is a potent inhibitor of *G6PD* and shows potent antimalarial activity .

HY-18705

Azoramide 4 Publications Verification	Apoptosis Reactive Oxygen Species Caspase Bcl-2 Family Mitochondrial Metabolism	Endocrinology
Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity .

Cat. No.	Product Name	Target	Research Area

HY-P0148

Gly6

HexaGlycine
Peptides Others

Gly6 (Hexaglycine) is a linear glycine oligopeptide with six glycines .
HY-P0148A

Gly6 hydrochloride

HexaGlycine hydrochloride
Peptides Others

Gly6 hydrochloride (Hexaglycine hydrochloride) is a linear glycine oligopeptide with six glycines .

*Gly6* HexaGlycine	Peptides	Others
Gly6 (Hexaglycine) is a linear glycine oligopeptide with six glycines .

Gly6 hydrochloride HexaGlycine hydrochloride	Peptides	Others
Gly6 hydrochloride (Hexaglycine hydrochloride) is a linear glycine oligopeptide with six glycines .

HY-P10109A

G6PI 325-339 (human) (hydrochloride) hG6PI (325-339) (hydrochloride)	Peptides	Inflammation/Immunology
G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms .

HY-P10109

G6PI 325-339 (human) hG6PI (325-339)	Peptides	Inflammation/Immunology
G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms .

Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse Ly-6G/Ly-6C Antibody is an anti-mouse Ly-6G/Ly-6C IgG2b antibody inhibitor.

Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)	Inhibitory Antibodies	Others
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse Ly6G/Ly6C.

7-Methoxyrosmanol 7-O-Methoxyrosmanol	other families Classification of Application Fields Terpenoids Source classification Other Diseases Phenols Polyphenols Diterpenoids Plants Disease Research Fields	Others
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

Polydatin 5+ Cited Publications Piceid	Structural Classification Classification of Application Fields Anti-aging Polygonaceae Reynoutria japonica Houtt. Source classification Plants Stilbenes Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Autophagy Apoptosis Mitophagy
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

Polydatin (Standard) 5+ Cited Publications Piceid (Standard)	Structural Classification Stilbenes Classification of Application Fields Anti-aging Polygonaceae Source classification Reynoutria japonica Houtt. Phenols Plants Inflammation/Immunology Disease Research Fields Cancer	Autophagy Apoptosis Mitophagy
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

Momordicine I	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	DGK
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .

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