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ICA

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Fluorescent Dye

1

Natural
Products

6

Recombinant Proteins

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Cat. No. Compare Product Name Species Source
  • HY-P73912
    ICA Protein, Mouse (HEK293, His)

    Inhibitor of carbonic anhydrase; ICA

    		 Mouse HEK293
    ICA Protein, a potent inhibitor of carbonic anhydrase 2 (CA2), intricately regulates enzymatic activity within a finely tuned network. Functionally, ICA, a non-iron-binding monomer, exhibits specificity in inhibiting CA2. Its transferrin-like domain 2 engages in molecular interactions, underscoring ICA's regulatory role. This positions ICA as a key player, adding nuance to the precise mechanisms governing carbonic anhydrase activity. ICA Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICA protein, expressed by HEK293 , with C-His labeled tag. The total length of ICA Protein, Mouse (HEK293, His) is 681 a.a., with molecular weight of ~76.2-80 kDa.
  • HY-P72274
    Islet cell autoantigen 1/ICA1, Human (P.pastoris, His)

    ICA69

    		 Human P. pastoris
    ICA1 may be involved in neurotransmitter secretion, suggesting involvement in synaptic transmission. It may help regulate the release of neurotransmitters, a key aspect of neuronal communication. Islet cell autoantigen 1/ICA1, Human (P.pastoris, His) is the recombinant human-derived Islet cell autoantigen 1/ICA1, expressed by P. pastoris , with N-6*His labeled tag. The total length of Islet cell autoantigen 1/ICA1, Human (P.pastoris, His) is 482 a.a., with molecular weight of ~62 kDa.
  • HY-P70847
    IA2 Protein, Human (293a.a, His)

    Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

    		 Human E. coli
    The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (293a.a, His) is 293 a.a., with molecular weight of ~34.86 kDa.
  • HY-P70848
    IA2 Protein, Human (365a.a, His)

    Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

    		 Human E. coli
    IA2 Protein is pivotal in vesicle-mediated secretory processes, crucial for secretory vesicle accumulation in the hippocampus, pituitary, and pancreatic islets. Essential for insulin-related functions, IA2 ensures normal insulin-containing vesicle levels, preventing degradation and promoting glucose-stimulated insulin secretion. IA2's influence extends to neurotransmitter regulation, required for normal norepinephrine, dopamine, and serotonin accumulation. In females, IA2 is uniquely essential for pituitary hormone accumulation and secretion. It also maintains normal renin expression. Despite lacking intrinsic enzyme activity, IA2 may regulate active protein-tyrosine phosphatases, like PTPRA, through dimerization. IA2's interaction with ICA512-TMF highlights its role in modulating insulin secretory granule dynamics and proposes a tethering mechanism to the actin cytoskeleton, dependent on UTRN and regulated by ICA512-CFF dimerization. IA2 Protein, Human (365a.a, His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (365a.a, His) is 375 a.a., with molecular weight of 45-50 kDa.
  • HY-P70847A
    IA2 Protein, Human (293a.a, N-His)

    Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

    		 Human E. coli
    IA2 Protein is pivotal in vesicle-mediated secretory processes, crucial for secretory vesicle accumulation in the hippocampus, pituitary, and pancreatic islets. Essential for insulin-related functions, IA2 ensures normal insulin-containing vesicle levels, preventing degradation and promoting glucose-stimulated insulin secretion. IA2's influence extends to neurotransmitter regulation, required for normal norepinephrine, dopamine, and serotonin accumulation. In females, IA2 is uniquely essential for pituitary hormone accumulation and secretion. It also maintains normal renin expression. Despite lacking intrinsic enzyme activity, IA2 may regulate active protein-tyrosine phosphatases, like PTPRA, through dimerization. IA2's interaction with ICA512-TMF highlights its role in modulating insulin secretory granule dynamics and proposes a tethering mechanism to the actin cytoskeleton, dependent on UTRN and regulated by ICA512-CFF dimerization. IA2 Protein, Human (293a.a, N-His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IA2 Protein, Human (293a.a, N-His) is 293 a.a., with molecular weight of ~35 kDa.
  • HY-P700427
    NRG1-beta 1 Protein, Human (HEK293, His)

    Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512

    		 Human HEK293
    NRG1-alpha protein acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concurrently recruiting ERBB1 and ERBB2 coreceptors, thereby inducing ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The diverse functions of its multiple isoforms encompass the induction of growth and differentiation in various cell types, including epithelial, glial, neuronal, and skeletal muscle cells. NRG1-alpha is also involved in the expression of acetylcholine receptors during neuromuscular junction formation, the stimulation of lobuloalveolar budding and milk production in the mammary gland, and the induction of differentiation in mammary tumor cells. Furthermore, it stimulates Schwann cell proliferation and plays a role in myocardial development, specifically contributing to the trabeculation of the developing heart. Isoform 10 is implicated in motor and sensory neuron development. NRG1-alpha binds to ERBB4 and ERBB3, acting as a ligand for integrins and forming a ternary complex with integrins and ERBB3, a crucial step in NRG1-ERBB signaling. It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2, and AKT1. Additionally, NRG1-alpha participates in ligand-dependent ERBB4 endocytosis, essential for the activation of these kinases in neurons, and interacts with the LIM domain region of LIMK1. It also forms a ternary complex with ERBB3 and integrins ITGAV:ITGB3 or ITGA6:ITGB4 and interacts with NRDC and BACE1. NRG1-beta 1 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NRG1-beta 1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of 27.1 kDa.

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