N-Acylethanolamines

By Targets:	Ceramidase (1) Endogenous Metabolite (1) FAAH (1) Fluorescent Dye (1) Glutathione Peroxidase (1) Nucleoside Antimetabolite/Analog (1) SARS-CoV (1) Virus Protease (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124597

ARN726	Others	Inflammation/Immunology
ARN726 is a potent *NAAA (N-acylethanolamine* acid amidase) inhibitor with an IC₅₀** of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner .

HY-145339

ARN19702	Others	Neurological Disease Inflammation/Immunology
ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC₅₀ of 230 nM for human NAAA. ARN19702 has pain relief effects .

HY-120813

ARN 077 URB913	Others	Inflammation/Immunology
ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC₅₀ of 7 nM for human NAAA . ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats .

HY-W721596

Pentadecanoyl ethanolamide	Endogenous Metabolite	Neurological Disease
Pentadecanoyl ethanolamide is derivate of endougenous lipid amides, the N-acylethanolamines. Pentadecanoyl ethanolamide exhibits anticonvulsant efficacy in electroshocked mice without significant toxicity .

HY-121975

N-Cyclohexanecarbonylpentadecylamine	Others	Inflammation/Immunology
N-Cyclohexanecarbonylpentadecylamine (Compound 1) is an inhibitor of N-Acylethanolamine hydrolyzing acid amidase (NAAA) with an IC₅₀ of 4.5 μM. N-Cyclohexanecarbonylpentadecylamine can be used in the research of inflammation and pain .

HY-B0182

Carmofur 3 Publications Verification HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-D2338

PMBD	Fluorescent Dye	Others
PMBD is a lysosome (Lyso)-targeting fluorescent probe. PMBD selectively and sensitively detects endogenous N-acylethanolamine amidase (NAAA), allowing real-time visual monitoring of endogenous NAAA in living cells. PMBD has a maximum absorption peak at 350 nm. After the metabolism of NAAA, the maximum absorption peak of the product AMBD shifts red to 450 nm, and a significant fluorescence emission signal appears at 550 nm .

HY-B0182R

Carmofur (Standard)		Infection Inflammation/Immunology Cancer
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-132882

ARN19689	Others	Inflammation/Immunology
ARN19689 is a potent, selective, orally active and non-covalent inhibitor of N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA), with an IC₅₀ of 42 nM. ARN19689 is a promising pharmacological tool to be further investigated in the field of inflammatory conditions .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .
HY-110138

PDP-EA

Others Others

PDP-EA is a compound that increases the amidohydrolase activity of FAAH (fatty acid amide hydrolase) .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

PDP-EA	Others	Others
PDP-EA is a compound that increases the amidohydrolase activity of FAAH (fatty acid amide hydrolase) .

Cat. No.	Product Name	Type

HY-D2338

PMBD	Fluorescent Dyes/Probes
PMBD is a lysosome (Lyso)-targeting fluorescent probe. PMBD selectively and sensitively detects endogenous N-acylethanolamine amidase (NAAA), allowing real-time visual monitoring of endogenous NAAA in living cells. PMBD has a maximum absorption peak at 350 nm. After the metabolism of NAAA, the maximum absorption peak of the product AMBD shifts red to 450 nm, and a significant fluorescence emission signal appears at 550 nm .

PMBD

Fluorescent Dyes/Probes

PMBD is a lysosome (Lyso)-targeting fluorescent probe. PMBD selectively and sensitively detects endogenous N-acylethanolamine amidase (NAAA), allowing real-time visual monitoring of endogenous NAAA in living cells. PMBD has a maximum absorption peak at 350 nm. After the metabolism of NAAA, the maximum absorption peak of the product AMBD shifts red to 450 nm, and a significant fluorescence emission signal appears at 550 nm .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121975

N-Cyclohexanecarbonylpentadecylamine	Structural Classification Natural Products Source classification Endogenous metabolite	Others
N-Cyclohexanecarbonylpentadecylamine (Compound 1) is an inhibitor of N-Acylethanolamine hydrolyzing acid amidase (NAAA) with an IC₅₀ of 4.5 μM. N-Cyclohexanecarbonylpentadecylamine can be used in the research of inflammation and pain .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

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