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Results for "

NOXA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) CXCR (1) Endogenous Metabolite (1) HDAC (1) Monoamine Oxidase (2) NADPH Oxidase (5) p97 (1) Sirtuin (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (3)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease
NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia .

HY-P5328

Noxa A BH3

NADPH Oxidase Others

Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P5330

Noxa B BH3

NADPH Oxidase Others

Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)

Noxa A BH3	NADPH Oxidase	Others
Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)

Noxa B BH3	NADPH Oxidase	Others
Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

HY-RS09465

NOXA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOXA1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOXA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOXA1 Human Pre-designed siRNA Set A NOXA1 Human Pre-designed siRNA Set A

HY-P5329

*r8-Gly-Noxa* A BH3**	NADPH Oxidase	Others
r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)

HY-114989

Fluorizoline 1 Publications Verification	Apoptosis	Cancer
Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner .

HY-148408

SIRT2-IN-11	Sirtuin	Cancer
SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC₅₀ value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers .

HY-110078

Eeyarestatin I 1 Publications Verification	p97 Apoptosis	Cancer
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .

HY-E70236

CoA-S-S-CoA

Endogenous Metabolite Others

CoA–S-S–CoA is an endogenous metabolite found inP. furiousus. CoA–S-S–CoA is a substrate of NOXA2 .

CoA-S-S-CoA	Endogenous Metabolite	Others
CoA–S-S–CoA is an endogenous metabolite found inP. furiousus. CoA–S-S–CoA is a substrate of NOXA2 .

HY-160041

Olaptesed pegol	CXCR	Cancer
Olaptesed pegol (NOX-A12) L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment .

HY-126324

IV-23	Apoptosis	Cancer
IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC) .

HY-149017

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .

HY-A0091

Pargyline hydrochloride 2 Publications Verification	Monoamine Oxidase	Cardiovascular Disease Cancer
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091A

Pargyline 2 Publications Verification	Monoamine Oxidase	Cardiovascular Disease Cancer
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155840

KH16	HDAC Apoptosis	Cancer
KH16 is a potent and low nanomolar HDAC inhibitor. KH16 is against class I HDACs HDAC1, HDAC2, and HDAC3, with IC₅₀ ?values ranging from 6 to 34 nM. KH16 induces cell apoptosis and is against tumor cells with various gene expression patterns .

Cat. No.	Product Name	Target	Research Area

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease
NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia .

HY-P5328

Noxa A BH3

NADPH Oxidase Others

Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
HY-P5330

Noxa B BH3

NADPH Oxidase Others

Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)

Noxa A BH3	NADPH Oxidase	Others
Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)

Noxa B BH3	NADPH Oxidase	Others
Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

HY-P5329

*r8-Gly-Noxa* A BH3**	NADPH Oxidase	Others
r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74656

	p67phox Protein, Human (sf9) Neutrophil cytosol factor 2; NCF-2; NOXA2; P67PHOX	Human	Sf9 insect cells
	p67phox is central to activating NADPH oxidase, crucial for superoxide production. Forming a heterodimer with CYBA and CYBB, and interacting with NCF4 and NCF1, p67phox establishes vital connections within the complex. Its versatile associations include SYTL1, RAC1, NOXO1, S100A8, calprotectin (S100A8/9), and GBP7, highlighting its regulatory role. Enhanced interaction with CYBB in the presence of GBP7 underscores the dynamic nature of these protein-protein associations in orchestrating superoxide generation. p67phox Protein, Human (sf9) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of p67phox Protein, Human (sf9) is 526 a.a., with molecular weight of ~60 kDa.

HY-P74655

	p67phox Protein, Human (sf9, His-GST) Neutrophil cytosol factor 2; NCF-2; NOXA2; P67PHOX	Human	Sf9 insect cells
	p67phox is central to the activation of NADPH oxidase, which is critical for superoxide production. p67phox forms heterodimers with CYBA and CYBB and interacts with NCF4 and NCF1 to establish important connections within the complex. p67phox Protein, Human (sf9, His-GST) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p67phox Protein, Human (sf9, His-GST) is 526 a.a., with molecular weight of 80-90 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P82808

NOXA Antibody (YA2553)

APR; ATL-derived; NOXA; Pmaip1; Protein NOXA
WB Human
HY-P81904

NOXA2 Antibody (YA1649)

Ncf2; NOXA2; P67 PHOX
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-A0091

Pargyline hydrochloride 2 Publications Verification		Alkynes
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091A

Pargyline 2 Publications Verification		Alkynes
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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