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Results for "

Notch3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Histone Demethylase (2) MMP (1) Notch (2) Small Interfering RNA (siRNA) (1) γ-secretase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

NSC 405020 1 Publications Verification	MMP	Cardiovascular Disease Cancer
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis ^[3].

S2116	Histone Demethylase Apoptosis	Cancer
S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice .

S2157	Histone Demethylase Apoptosis	Cancer
S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells .

BMS-986115 1 Publications Verification Notch inhibitor 1	Notch	Cancer
BMS-986115 (Notch inhibitor 1) is a potent *Notch* inhibitor, with IC₅₀s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer .

NOTCH3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NOTCH3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NOTCH3 Human Pre-designed siRNA Set A NOTCH3 Human Pre-designed siRNA Set A

BMS-906024 2 Publications Verification	γ-secretase Notch	Cancer
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC₅₀s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .

Recombinant Proteins Recommended:

Cat. No.	Compare	Product Name	Species	Source

	Notch3 Protein, Human (HEK293, Fc) CADASIL; CASILneurogenic locus Notch homolog protein 3; Notch (Drosophila) homolog 3; Notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3	Human	HEK293
	Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch3 Protein, Human (HEK293, Fc) is the recombinant human-derived Notch3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Notch3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 75-83 kDa.

	Notch 3 Protein, Human (HEK293, His-Avi) CADASIL; Notch homolog 3; Notch-3; Notch3	Human	HEK293
	Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch 3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Notch 3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Notch 3 Protein, Human (HEK293, His-Avi) is 428 a.a., with molecular weight of 53-60 kDa.

	Notch 3 Protein, Human (Biotinylated, HEK293, His-Avi) CADASIL; Notch homolog 3; Notch-3; Notch3	Human	HEK293
	Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch 3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Notch 3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Notch 3 Protein, Human (Biotinylated, HEK293, His-Avi) is 428 a.a., with molecular weight of 55-65 kDa.

	Notch 3 Protein, Human (HEK293, C-His-Avi) CADASIL; Notch homolog 3; Notch-3; Notch3	Human	HEK293
	Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch 3 Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived Notch 3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Notch 3 Protein, Human (HEK293, C-His-Avi) is 263 a.a., with molecular weight of 27-30 kDa & 10-12 kDa, respectively.

	NOTCH4 Protein, Human (sf9, His) Neurogenic locus Notch homolog protein 4; hNotch4; INT3	Human	Sf9 insect cells
	NOTCH4 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH4 Protein, Human (sf9, His) is the recombinant human-derived NOTCH4 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of NOTCH4 Protein, Human (sf9, His) is 637 a.a., with molecular weight of ~66.1 kDa.


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