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Results for "

OAT1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15258
    Lesinurad
    2 Publications Verification

    RDEA594

    		 URAT1 Metabolic Disease
    Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad
  • HY-15258A
    Lesinurad sodium
    2 Publications Verification

    RDEA-594 sodium

    		 URAT1 Metabolic Disease
    Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad sodium
  • HY-15592
    Cabotegravir
    Maximum Cited Publications
    7 Publications Verification

    GSK-1265744; S/GSK1265744

    		 HIV HIV Integrase Infection
    Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS [1] .
    Cabotegravir
  • HY-N12007
    OAT1/3-IN-1

    		Others Metabolic Disease
    OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage [1].
    <em>OAT1</em>/3-IN-<em>1</em>
  • HY-N12008
    OAT1/3-IN-2

    		Others Metabolic Disease
    OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage [1].
    <em>OAT1</em>/3-IN-2
  • HY-15592A
    Cabotegravir sodium
    Maximum Cited Publications
    7 Publications Verification

    GSK-1265744 sodium; S/GSK1265744 sodium

    		 HIV HIV Integrase Infection
    Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS [1] .
    Cabotegravir sodium
  • HY-163431
    URAT1 inhibitor 10

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 [1].
    URAT<em>1</em> inhibitor 10
  • HY-111345
    Epaminurad

    UR-1102; URC-102

    		 URAT1 Metabolic Disease Inflammation/Immunology
    Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research [1].
    Epaminurad
  • HY-144305
    KPH2f

    		URAT1 GLUT Infection
    KPH2f is a safe, orally active, and effective dual URAT1/GLUT9 inhibitor with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively. KPH2f shows little effects on OAT1 and ABCG2 (IC50=32.14 and 26.74 μM) [1].
    KPH2f
  • HY-122009
    Indican

    Indoxyl-β-D-glucoside

    		 Fluorescent Dye Others
    Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 [1] .
    Indican
  • HY-148682
    18β-Glycyrrhetyl-3-O-sulfate

    Glycyrrhetic acid 3-O-hydrogen sulfate

    		 11β-HSD Drug Metabolite Metabolic Disease Inflammation/Immunology
    18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research [1] .
    18β-Glycyrrhetyl-3-O-sulfate
  • HY-151432
    URAT1 inhibitor 3

    		URAT1 Inflammation/Immunology
    URAT1 inhibitor 3 is a potent, orally active, selective URAT1 inhibitor with an IC50 value of 0.8 nM. URAT1 inhibitor 3 has urate-lowering efficacy. URAT1 inhibitor 3 can be used in research of gout and hyperuricemi [1].
    URAT<em>1</em> inhibitor 3

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