Rho-kinase

By Targets:	ROCK (16) Apoptosis (1) Aurora Kinase (1) CaMK (1) Organoid (1) PKA (1) PKC (1) SGK (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (8)

Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112362

3-(4-Pyridyl)indole Rockout; 3-(4-Pyridinyl)-1H-indole; Rho kinase Inhibitor III, Rockout	ROCK	Inflammation/Immunology
3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC₅₀ of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay .

HY-150640

Rho-Kinase-IN-2	ROCK	Neurological Disease
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC₅₀=3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research .

HY-100270

Rho-Kinase-IN-1	ROCK	Cancer
Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (K_i values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .

HY-N6012

(-)-Alkannin	Apoptosis	Inflammation/Immunology Cancer
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

HY-118151

Rho-Kinase-IN-3	ROCK	Neurological Disease
Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC₅₀ value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension .

HY-10583

Y-27632 dihydrochloride 225+ Cited Publications	Organoid ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

HY-16758

Verosudil AR-12286	ROCK	Neurological Disease
Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with K_is of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork .

HY-15720B

Glycyl H-1152 hydrochloride	ROCK Aurora Kinase CaMK	Neurological Disease
Glycyl H-1152 hydrochloride (compound 18) is a glycyl derivative of Rho-kinase inhibitors H-1152 dihydrochloride. Glycyl H-1152 hydrochloride inhibits ROCKII, Aurora A, CAMKII and PKG, with IC₅₀s of 0.0118, 2.35, 2.57 and 3.26 μM respectively. Glycyl H-1152 hydrochloride has higher selective than H-1152 hydrochloride .

HY-10583G

Y-27632 dihydrochloride	ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

HY-126913

Rhodblock 6

ROCK Cancer

Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .

Rhodblock 6	ROCK	Cancer
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .

HY-12798A

Netarsudil dimesylate AR-13324 dimesylate
Netarsudil mesylate (AR-13324 mesylate) is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter; reduces intraocular pressure (IOP) in normotensive monkey eyes.

HY-108518

SB-772077B dihydrochloride	ROCK	Cardiovascular Disease
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC₅₀s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively .

HY-16563

Narciclasine 10+ Cited Publications Lycoricidinol	ROCK	Cancer
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-122011

PF-4950834	ROCK SGK PKA PKC	Inflammation/Immunology
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive *rho kinase* inhibitor with IC₅₀ values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration .

HY-139170

CAY10746	ROCK	Metabolic Disease
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .

HY-109191

Sovesudil PHP-201; AMA0076	ROCK	Others
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .

HY-109191A

Sovesudil hydrochloride PHP-201 hydrochloride; AMA0076 hydrochloride	ROCK	Neurological Disease
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .

Cat. No.	Product Name	Type

HY-10583G

Y-27632 dihydrochloride (GMP)	Fluorescent Dye
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

Cat. No.	Product Name	Type

HY-10583G

Y-27632 dihydrochloride (GMP)	Biochemical Assay Reagents
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

Cat. No.	Product Name	Target	Research Area

HY-P5467

S6(229-239), Amide, biotinalyted

Peptides Others

S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

S6(229-239), Amide, biotinalyted	Peptides	Others
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6012

(-)-Alkannin	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Plants Inflammation/Immunology Disease Research Fields Boraginaceae Alkanna tinctoria L. Shikonin	Apoptosis
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway .

HY-16563

Narciclasine 10+ Cited Publications Lycoricidinol	Structural Classification Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Isoquinoline Alkaloids Disease Research Fields Amaryllidaceae Cancer Agricultural Research	ROCK
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Cat. No.	Product Name	Application	Reactivity

HY-P81922

ROCK2 Antibody (YA1667)

p164 ROCK 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha
WB, ICC/IF Human, Rat

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Rho-kinase

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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