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Results for "

RyR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Calcium Channel (9) Parasite (5) Small Interfering RNA (siRNA) (3) Topoisomerase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149779

RyR2 stabilizer-1	Calcium Channel	Cardiovascular Disease
RyR2 stabilizer-1 (compound 12a) is a potent *RyR2* stabilizer and SERCA2a activator with EC₅₀s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca ²⁺ leakage from the SR RyR2 while promoting SERCA2 to pump Ca ²⁺ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias .

HY-RS12368

RYR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR1 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR1 Human Pre-designed siRNA Set A RYR1 Human Pre-designed siRNA Set A

HY-RS12369

RYR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR2 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR2 Human Pre-designed siRNA Set A RYR2 Human Pre-designed siRNA Set A

HY-RS12370

RYR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RYR3 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RYR3 Human Pre-designed siRNA Set A RYR3 Human Pre-designed siRNA Set A

HY-146109

RyRs activator 1	Parasite	Infection
RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .

HY-146110

RyRs activator 2	Parasite	Infection
RyRs activator 2 (compound 7o) is a potent activator of ryanodine receptors (RyRs). RyRs activator 2 is 30% larvicidal activity, comparable to chlorantraniliprole (30%) and better than cyantraniliprole (10%) .

HY-156082

RyRs activator 3	Parasite Calcium Channel	Others
RyRs activator 3 (compound A4) is an effective insecticide against diamondback moths (M. separata) and diamondback moths (P. xylostella). The LC50 value of RyRs activator 3 against diamondback moth is 3.27 mg/L. RyRs activator 3 can bind to ryanodine receptor, increase cytoplasmic Ca2+ concentration, and produce biological toxicity .

HY-155334

RyRs activator 4	Others	Others
RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC₅₀ value of 1.32 mg/L .

HY-155394

RyRs activator 5

Others Metabolic Disease

RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .

RyRs activator 5	Others	Metabolic Disease
RyRs activator 5 (Compd A-1) is an active ryanodine receptor agonist against Spodoptera frugiperda .

HY-P3037

Imperatoxin A	Calcium Channel
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-149662

TMDJ-035	Calcium Channel	Inflammation/Immunology
TMDJ-035 is a selective *RyR2* inhibitor. TMDJ-035 suppresses abnormal Ca ²⁺ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035is a tool for studying the mechanism and dynamics of RyR2 channel gating .

HY-N7491A

Ent-(+)-Verticilide	Calcium Channel	Cancer
ent-(+)-verticilide is a potent and selective inhibitor of *cardiac ryanodine receptor (RyR2) calcium release channels* with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca ²⁺?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .

HY-12542

Dantrolene Maximum Cited Publications 7 Publications Verification F 368	Calcium Channel Autophagy	Neurological Disease Inflammation/Immunology
Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene is a direct-acting skeletal muscle relaxant. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-12542A

Dantrolene sodium hemiheptahydrate Maximum Cited Publications 7 Publications Verification Dantrolene sodium hydrate	Calcium Channel Autophagy	Others
Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K_i of 111.6 μM and an IC₅₀ of 52.3 μM. Dantrolene sodium hemiheptahydrate is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer. Dantrolene sodium hemiheptahydrate is a direct-acting skeletal muscle relaxant. Dantrolene sodium hemiheptahydrate can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

HY-15292

S107 1 Publications Verification	Others	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes *RyR2* channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca ²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .

HY-149697

Insecticidal agent 6	Parasite	Others
Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC₅₀ value of 0.6308 µM against S. frugiperda *RyRs*. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases .

HY-113920A

Azumolene EU4093 free base	Calcium Channel	Metabolic Disease
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research .

HY-138806

PAQ	Others	Neurological Disease
PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells .

HY-163157

Insecticidal agent 7	Parasite	Others
Insecticidal agent 7 (Compound 21m) is an insecticide that targets the insect ryanodine receptors (RyRs) with a LC₅₀ of 0.0937 mg/L for the Plutella xylostella. Insecticidal agent 7 (Compound 21m) exhibits good selectivity and low toxicity towards non-target organisms .

HY-101775A

9-Hydroxyellipticine hydrochloride	Topoisomerase	Cardiovascular Disease Cancer
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and *RyR*. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P5424

RyR1(3614-3643)

Peptides Others

RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)

RyR1(3614-3643)	Peptides	Others
RyR1(3614-3643) is a biological active peptide. (the absolutely conserved peptide corresponding to the CaM-binding domain of RyR1 in all vertebrates)

HY-P3037

Imperatoxin A	Calcium Channel
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs)? enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5494

DPc10	Peptides	Others
DPc10 is a biological active peptide. (This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.)

HY-P5319

MCaE12A	Peptides	Others
MCaE12A is a high-affinity modulator of *RyR2* and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques .

9-Hydroxyellipticine hydrochloride	Structural Classification Alkaloids Carbazole Alkaloids	Topoisomerase
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and *RyR*. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC₅₀ values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively .

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RyR

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