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Results for "

TMPRSS2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ack1 (1) Androgen Receptor (1) Autophagy (2) Cathepsin (1) HIV (2) Isotope-Labeled Compounds (1) PAI-1 (1) Parasite (1) SARS-CoV (13) Ser/Thr Protease (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Endocrinology (1) Infection (12) Inflammation/Immunology (2) Metabolic Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 ^[2].

HY-RS14769

TMPRSS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TMPRSS2 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TMPRSS2 Human Pre-designed siRNA Set A TMPRSS2 Human Pre-designed siRNA Set A

HY-B1624

Debrisoquin Debrisoquine; Isocaramidine; Ro 5-3307/1	SARS-CoV Ser/Thr Protease	Infection
Debrisoquin (Isocaramidine) is a *TMPRSS2* inhibitors that inhibits *SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀* of 22μM. Debrisoquin can be used for antiviral research .

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-134432A

Boc-Gln-Ala-Arg-AMC hydrochloride	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 ^[2].

HY-B1624A

Debrisoquin hemisulfate Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate
Debrisoquin (Isocaramidine) hemisulfate is a *TMPRSS2* inhibitors that inhibits *SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀* of 22μM. Debrisoquin hemisulfate can be used for antiviral research .

HY-130402B

Propamidine

Parasite Infection

Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .

Propamidine	Parasite	Infection
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .

HY-13512

Camostat mesylate Maximum Cited Publications 28 Publications Verification Camostat mesilate; FOY305; FOY-S980	Ser/Thr Protease SARS-CoV	Infection Inflammation/Immunology
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of *TMPRSS2, shows antiviral activity against SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase ^[2] .

HY-B0372A

Bromhexine hydrochloride 3 Publications Verification	SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine hydrochloride is a potent and specific *TMPRSS2* protease inhibitor with an IC₅₀ of 0.75 μM. Bromhexine hydrochloride can prevent and manage *SARS-CoV-2* infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions ^[2] .

HY-163067

SARS-CoV-2-IN-71	SARS-CoV	Infection
SARS-CoV-2-IN-71 (compound 8h) is a potent inhibitor of *SARS-CoV-2. SARS-CoV-2-IN-71 inhibits coronavirus replication at multiple stages. SARS-CoV-2-IN-71 displays anti-coronaviral effect by simultaneously acting on 3CL ^pro* and *TMPRSS2* .

HY-161370

VD4162	Ser/Thr Protease	Cancer
VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC₅₀ = 3.7 nM), HGFA(IC₅₀ = 3.3 nM), matriptase (IC₅₀ = 2.9 nM), and hepsin (IC₅₀ = 0.54 nM). VD4162 can be used for the research of cancer .

HY-157021

SARS-CoV-2-IN-66	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2-IN-66 (1), a vitaminK derivative, is a SARS-CoV-2 inhibitor, with an EC₅₀ of 70.8 μM in VeroE6/TMPRSS2 cells .

HY-108447

BC-11 hydrobromide	Ser/Thr Protease SARS-CoV PAI-1	Infection Cancer
BC-11 hydrobromide is a selective *TMPRSS2* inhibitor (TMPRSS2 is a key host cellular factor for viral entry and *SARS-CoV-2* pathogenesis), and a selective urokinase (uPA) inhibitor (IC₅₀=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer ^[2] .

HY-156441

SARS-CoV-2-IN-65	SARS-CoV	Infection
SARS-CoV-2-IN-65 (compound 2f (81)) is a potent,orally active and reversible *SARS-CoV-2* entry inhibitor. SARS-CoV-2-IN-65 inhibits the pseudovirus entry in a ACE2-dependent pathway, via mainly inhibiting RBD:ACE2 interaction and TMPRSS2 activity in Calu-3 cells .

HY-157022

SARS-CoV-2-IN-67	SARS-CoV	Infection
SARS-CoV-2-IN-67 (Compound 16), a vitamin K derivatives, has anti-SARS-CoV-2 activity (EC₅₀: 64.8 μM in VeroE6/TMPRSS2 cells). SARS-CoV-2-IN-67 inhibits SARS-CoV-2 RdRp activity .

HY-163029

CTSL/B-IN-1	Cathepsin SARS-CoV	Infection
CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and *TMPRSS2* with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant *SARS-CoV-2* viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .

HY-158073

ML2006a4	SARS-CoV	Infection
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (M ^pro) with IC₅₀ in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level

HY-B0372AS

Bromhexine-d3 hydrochloride	Isotope-Labeled Compounds SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].

HY-157154

MAT-POS-e194df51-1	SARS-CoV	Infection
MAT-POS-e194df51-1 is an orally active, non-covalent and non-peptide *SARS-CoV-2* main protease (M ^pro) inhibitor with an IC₅₀ value of 37nM. MAT-POS-e194df51-1 is cytotoxic with EC₅₀ values of 64 nM and 126 nM in A549-ACE2-TMPRSS2 cells and HeLa -ACE2 cells, respectively .

HY-15290

AIM-100 3 Publications Verification	Ack1	Cancer
AIM-100 is a potent and selective Ack1 inhibitor with an IC₅₀ of 21.58 nM. AIM-100 also inhibits Tyr ²⁶⁷ phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect ^[2].

HY-135794

11-Ketodihydrotestosterone 11-KDHT; 5α-Dihydro-11-keto testosterone	Androgen Receptor	Endocrinology
11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a K_i of 20.4 nM and an EC₅₀ of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells ^[2].

Cat. No.	Product Name	Type

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate	Dyes
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 ^[2].

Cat. No.	Product Name	Target	Research Area

HY-134432B

Boc-Gln-Ala-Arg-AMC acetate	Ser/Thr Protease	Others
Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC acetate can also be used for measuring the proteolytic activity of TMPRSS2 ^[2].

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (1) P. pastoris (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72043

	TMPRSS2 Protein, Human (P.pastoris, His) 1 Publications Verification Serine protease 10; PRSS10	Human	P. pastoris
	The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (P.pastoris, His) is the recombinant human-derived TMPRSS2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of TMPRSS2 Protein, Human (P.pastoris, His) is 387 a.a., with molecular weight of ~45 kDa.

HY-P72044

	TMPRSS2 Protein, Human (R255Q, HEK293, His) Serine protease 10	Human	HEK293
	The TMPRSS2 protein is a plasma membrane-anchored serine protease that plays critical roles in prostate physiology, cancer metastasis, pain modulation, and viral infection. Its lytic activity affects proteolytic cascades involved in prostate function, and androgen-induced activation contributes to cancer progression. TMPRSS2 Protein, Human (R255Q, HEK293, His) is the recombinant human-derived TMPRSS2 protein, expressed by HEK293 , with N-10*His labeled tag and R255Q, , , , mutation. The total length of TMPRSS2 Protein, Human (R255Q, HEK293, His) is 387 a.a., with molecular weight of ~46.71 kDa.

HY-P71733

	ERG Protein, Human (P.pastoris, His) ERG3; included; ets related; ETS-related gene; KCNH2; Oncogene TMPRSS2/ERG fusion	Human	P. pastoris
	ERG Protein, a transcriptional regulator, recruits SETDB1 histone methyltransferase to modify local chromatin. It interacts with SETDB1 and is identified in an IGF2BP1-dependent mRNP granule complex with untranslated mRNAs. ERG Protein, Human (P.pastoris, His) is the recombinant human-derived ERG protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ERG Protein, Human (P.pastoris, His) is 486 a.a., with molecular weight of ~57 kDa.


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Bromhexine-d3 hydrochloride
Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P82611

Transmembrane Protease Serine 2 Antibody (YA2356)

Epitheliasin; PRSS10; TMPRSS2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

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