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Results for "

Trypanocidal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) COX (1) Parasite (14)
By Research Areas:	Cancer (1) Infection (12) Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155401

Antitrypanosomal agent 18	Parasite	Others
Antitrypanosomal agent 18 (compound 8b) is a nitrofuran derivative has strong trypanocidal activity in vitro with an IC₅₀ value of 0.03 μM .

HY-149985

Antitrypanosomal agent 12	Parasite	Infection
Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI₅₀) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597) .

HY-N10303

Withangulatin A	COX Parasite	Inflammation/Immunology Cancer
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function .

HY-N1985

Acetylastragaloside I	Parasite	Infection
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi*, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-N2848

α-Lapachone

Parasite Infection

α-Lapachone shows trypanocidal activity .
HY-155400

Antitrypanosomal agent 17

Parasite Infection

Antitrypanosomal agent 17 (Compd 7a) possesses antiamastigote activity, with an IC₅₀ of 0.03 μM against T. congolense strain IL3000 .
HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

α-Lapachone	Parasite	Infection
α-Lapachone shows trypanocidal activity .

Antitrypanosomal agent 17	Parasite	Infection
Antitrypanosomal agent 17 (Compd 7a) possesses antiamastigote activity, with an IC₅₀ of 0.03 μM against T. congolense strain IL3000 .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-149986

Antitrypanosomal agent 13	Parasite	Infection
Antitrypanosomal agent 13 (compound 4b) is a potent antitrypanosomal agent. Antitrypanosomal agent 13 has trypanocidal and cytotoxic activity with GI₅₀ values of 0.18 and 8.4 μM for T. brucei and HL-60, respectively .

HY-N3418

Kolavenol	Parasite	Infection
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

HY-N2449

(±)-Licarin A (±)-trans-Dehydrodiisoeugenol	Parasite	Infection
(±)-Licarin A ((±)-trans-Dehydrodiisoeugenol) is a dihydrobenzofuran neolignan, the resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. (±)-Licarin A displays 58.7% parasite lysis and has an IC₅₀ value of 100.8 µM for trypanocidal activity against trypomastigote forms of T. cruzi. And (±)-Licarin A shows 100% parasites mortality at 200 µM .

HY-13801

Fexinidazole HOE 239	Parasite	Infection
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC₅₀s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei .

HY-N0397

Harpagide	Parasite	Infection Inflammation/Immunology
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-12404

Diminazene aceturate 5 Publications Verification Diminazene diaceturate	Parasite Angiotensin-converting Enzyme (ACE)	Infection Inflammation/Immunology
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .

HY-13801R

Fexinidazole (Standard)	Parasite	Infection
Fexinidazole (Standard) is the analytical standard of Fexinidazole. This product is intended for research and analytical applications. Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC₅₀s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei .

α-Lapachone	Infection Quinones Structural Classification Classification of Application Fields Source classification Plants Compositae Derris indica Naphthalene Quinones Disease Research Fields	Parasite
α-Lapachone shows trypanocidal activity .

Withangulatin A	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	COX Parasite
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function .

Acetylastragaloside I	Structural Classification Natural Products Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Parasite
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC₅₀ values of 9.5 and 5.0 μg/mL for *T. brucei rhodesiense* and *T. cruzi*, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Kolavenol	Structural Classification Terpenoids Source classification Diterpenoids Solidago altissima Linnaeus Plants Compositae	Parasite
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC₅₀ value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .

Harpagide	Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Parasite
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

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Trypanocidal

Inhibitors & Agonists

NaturalProducts

Natural
Products