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Results for "

anti-leukemic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Antibiotic (2) Apoptosis (19) Arginase (3) Autophagy (6) Bacterial (3) Bcr-Abl (1) BCRP (1) c-Myc (2) Casein Kinase (2) Caspase (1) CDK (4) CMV (1) CRM1 (1) Cytochrome P450 (1) DNA/RNA Synthesis (6) Dopamine Receptor (2) Endogenous Metabolite (3) Fat Mass and Obesity-associated Protein (FTO) (1) Flavivirus (1) FLT3 (2) Fungal (2) HDAC (1) Histone Demethylase (1) Histone Methyltransferase (6) Interleukin Related (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) Nucleoside Antimetabolite/Analog (5) PI3K (1) SHMT (1) Src (1) STAT (1) Topoisomerase (3)
By Research Areas:	Cancer (52) Endocrinology (2) Infection (5) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)

By Targets:

Adrenergic Receptor (2)

Antibiotic (2)

Apoptosis (19)

Arginase (3)

Autophagy (6)

Bacterial (3)

Bcr-Abl (1)

BCRP (1)

c-Myc (2)

Casein Kinase (2)

Caspase (1)

CDK (4)

CMV (1)

CRM1 (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (6)

Dopamine Receptor (2)

Endogenous Metabolite (3)

Fat Mass and Obesity-associated Protein (FTO) (1)

Flavivirus (1)

FLT3 (2)

Fungal (2)

HDAC (1)

Histone Demethylase (1)

Histone Methyltransferase (6)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (1)

Nucleoside Antimetabolite/Analog (5)

PI3K (1)

SHMT (1)

Src (1)

STAT (1)

Topoisomerase (3)

By Research Areas:

Cancer (52)

Endocrinology (2)

Infection (5)

Inflammation/Immunology (4)

Metabolic Disease (5)

Neurological Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153274

CWI1-2	Apoptosis	Cancer
CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-N3401

Lasiodiplodin

Others Cancer

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .
HY-133900

Deoxyharringtonine

Others Cancer

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .

Lasiodiplodin	Others	Cancer
Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .

Deoxyharringtonine	Others	Cancer
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .

HY-N8402

Germacrone 4,5-epoxide	Others	Cancer
Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities .

HY-153274A

CWI1-2 hydrochloride	Apoptosis	Cancer
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .

HY-134333

ICCB280	Apoptosis	Cancer
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc) .

HY-123954

Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A51 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-112885C

nor-NOHA dihydrochloride 1 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism .

HY-112885B

nor-NOHA monoacetate 1 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Metabolic Disease
nor-NOHA monoacetate is a selective and reversible arginase inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-P99412

Lusvertikimab OSE-127	Interleukin Related	Cancer
Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody. Lusvertikimab is not internalized by target cells and prevents IL7R heterodimerization and subsequent downstream signaling. Lusvertikimab has anti-leukemic efficacy and has the potential for B cell precursor acute lymphoblastic leukemia (BCP-ALL) research .

HY-135190

(-)-Cedrene 1 Publications Verification α-cedrene	Bacterial	Infection Metabolic Disease Cancer
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities .

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-N10071

Poricoic acid G	Others	Cancer
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism .

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 µM .

HY-141429

AS-99 free base	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-141429C

AS-99	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-151411

RUNX1/ETO tetramerization-IN-1	Others	Cancer
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO (EC₅₀=0.25 μM), restores gene expression down-regulated by RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO-depending SKNO-1 cells, and reduces the RUNX1/ETO-related tumor growth in a mouse model .

HY-141429A

AS-99 TFA	Histone Methyltransferase Apoptosis	Cancer
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-112041

Unesbulin 3 Publications Verification PTC596	Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-100423

Eltanexor 1 Publications Verification KPT-8602
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC₅₀=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines .

HY-157327

AKE-72	Bcr-Abl	Cancer
AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABL ^WT, BCR-ABL ^T315, BCR-ABL ^E255K, BCR-ABL ^F3171, BCR-ABL ^H396P and BCR-ABL ^Q252H with IC₅₀s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line .

HY-N7549

Dehydrobruceantin

Others Cancer

Dehydrobruceantin has potential antileukemic activity .
HY-N3171A

(+)-Nortrachelogenin

Wikstromol
Apoptosis PI3K Cancer

(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

Dehydrobruceantin	Others	Cancer
Dehydrobruceantin has potential antileukemic activity .

(+)-Nortrachelogenin Wikstromol	Apoptosis PI3K	Cancer
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-17381

Idarubicin hydrochloride Maximum Cited Publications 11 Publications Verification 4-Demethoxydaunorubicin hydrochloride	Topoisomerase Bacterial Fungal Autophagy Antibiotic DNA/RNA Synthesis c-Myc	Infection Cancer
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.

HY-13677

6-Mercaptopurine 5+ Cited Publications Mercaptopurine; 6-MP	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

HY-U00095

Hepsulfam NCI 329680; ZINC01574758	Others	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-N7153

10-Hydroxycanthin-6-one

Others Cancer

10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .

10-Hydroxycanthin-6-one	Others	Cancer
10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent .

HY-125067

Yadanzioside P	Others	Cancer
Yadanzioside P is an *antileukemic* quassinoid glycoside. Yadanzioside P can be isolated from the seeds of Brucea javanica (L.). Yadanzioside P can be used for the research of cancer .

HY-N0838

Cephalotaxine (-)-Cephalotaxine; ZINC19795976	Flavivirus	Infection Cancer
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity .

HY-13677A

6-Mercaptopurine hydrate 5+ Cited Publications Mercaptopurine hydrate; 6-MP hydrate	Nucleoside Antimetabolite/Analog	Cancer
6-Mercaptopurine hydrate (Mercaptopurine hydrate; 6-MP hydrate) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-123523

Enocitabine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CMV	Infection Cancer
Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities .

HY-118144

PD166326	BCRP Src	Cancer
PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, with IC₅₀s of 6 nM and 8 nM for Src and Abl, respectively. PD166326 exhibits antileukemic activity .

HY-102048

STAT5-IN-2

2 Publications Verification

STAT Apoptosis Cancer

STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect .

STAT5-IN-2 2 Publications Verification	STAT Apoptosis	Cancer
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect .

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-109117

Iadademstat ORY-1001	Histone Demethylase	Cancer
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research .

HY-149334

ZLD115	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease
ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines .

HY-115754

S-(N-PhenethylthiocarbaMoyl)-L-cysteine PEITC-Cys	DNA/RNA Synthesis Cytochrome P450	Cancer
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells . S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .

HY-147717

CDK8-IN-7	CDK	Cancer
CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an K_d of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer .

HY-147716

CDK8-IN-6	CDK	Cancer
CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an K_d of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer .

HY-13677S

6-Mercaptopurine-d2 Mercaptopurine-d₂; 6-MP-d₂	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine-d₂ is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent[1][2].

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-13677S1

6-Mercaptopurine-13C2,15N Mercaptopurine-¹³C₂,¹⁵N; 6-MP-¹³C₂,¹⁵N	Nucleoside Antimetabolite/Analog Autophagy Endogenous Metabolite	Cancer
6-Mercaptopurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

HY-15003

ATH686	FLT3 Apoptosis	Cancer
ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects .

HY-17381A

Idarubicin 4-Demethoxydaunorubicin	Topoisomerase Bacterial Fungal Autophagy c-Myc DNA/RNA Synthesis Antibiotic	Infection Cancer
Idarubicin is an orally active and potent anthracycline antileukemic agent. Idarubicin inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin shows induction of DNA damage. Idarubicin inhibits DNA synthesis and of c-myc expression. Idarubicin inhibits the growth of bacteria and yeasts .

HY-P2970

Stem bromelain	Apoptosis	Inflammation/Immunology Cancer
Stem bromelain (EC 3.4.22.32) is a cysteine proteinase, isolated from pineapple (Ananas comosus) stem. Stem bromelain is a major bromelain, which exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Stem bromelain has in vivo antitumoral and antileukemic activity, as well as antimetastatic action .

HY-135231

NL-1 1 Publications Verification	Mitochondrial Metabolism Autophagy	Cancer
NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC₅₀s of 47.35 µM and 56.26 µM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway .

HY-151897

HDAC-IN-49	HDAC	Cancer
HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC₅₀s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-135190

(-)-Cedrene 1 Publications Verification α-cedrene	Infection Structural Classification Cedrus deodara (Roxburgh) G. Don Classification of Application Fields Pinaceae Terpenoids Sesquiterpenes Source classification Metabolic Disease Plants Disease Research Fields	Bacterial
(-)-Cedrene (α-cedrene) is a sesquiterpene constituent of cedarwood oils, with anti-leukemic, antimicrobial and anti-obesity activities .

HY-N3401

Lasiodiplodin	Structural Classification Natural Products Microorganisms Source classification	Others
Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .

HY-N8402

Germacrone 4,5-epoxide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Zingiberaceae	Others
Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities .

HY-N10071

Poricoic acid G	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N7549

Dehydrobruceantin	Triterpenes Structural Classification Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Source classification Plants	Others
Dehydrobruceantin has potential antileukemic activity .

HY-N3171A

(+)-Nortrachelogenin Wikstromol	Structural Classification Natural Products Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Wikstroemia indica	Apoptosis PI3K
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .