catalyses

By Targets:	Amylases (1) Antifolate (1) Apoptosis (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (3) Enolase (1) IKK (1) Integrin (1) NF-κB (1) PKC (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141412

D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Enolase	Infection
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalysed process of glycolysis. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase .

HY-108903

Hyaluronidase (human recombinant) Hylenex; Vorhyaluronidase alfa; rHuPH 20	Others	Cancer
Hyaluronidase (human recombinant) (Hylenex; Vorhyaluronidase alfa; rHuPH 20),catalysing the degradation of hyaluronic acid, is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents .

HY-P2723

Dextran sucrase	Endogenous Metabolite	Metabolic Disease
Dextran sucrase is an extracellular glucosyltransferase (GTF) that catalyses the transfer of D-glucopyranosyl residues from sucrose to dextran .

HY-148051

Ilaprazole sulfone	Drug Metabolite	Inflammation/Immunology Cancer
Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor .

HY-P3764

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

HY-112134

CSN5i-3 5+ Cited Publications	Others	Cancer
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC₅₀ value of 5.8 nM .

HY-E70010

Aldose 1-epimerase mutarotases	Endogenous Metabolite	Others
Aldose 1-epimerase (mutarotases) is a key enzyme of carbohydrate metabolism catalysing the interconversion of the α- and β-anomers of hexose sugars such as glucose and galactose. Aldose 1-epimerase is essential for normal carbohydrate metabolism and the production of complex oligosaccharides .

HY-P2968

Bacterial α-Amylase	Amylases	Others
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-P1923

L-Asparaginase 5+ Cited Publications L-ASNase	Apoptosis DNA/RNA Synthesis	Cancer
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .

HY-14518

Aminopterin 4-Aminofolic acid; APGA	Antifolate	Inflammation/Immunology Cancer
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K_i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia .

HY-W013557

3-Hydroxyxanthone 3-Hydroxy-xanthen-9-one	Integrin	Inflammation/Immunology
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) is a xanthone compound, with . 3-Hydroxyxanthone inhibits NADPH-catalysed lipid peroxidation in human umbilical vein endothelial cells (HUVECs). 3-Hydroxyxanthone also inhibits TNF-alpha induced ICAM-1 expression .

HY-P2962

Transglutaminase, Streptoverticillium mobaraense TG	Others	Infection Inflammation/Immunology
Transglutaminase, Streptoverticillium mobaraense (TG) is an enzyme that forms crosslinks between protein molecules. Transglutaminase catalyses the formation of an isopeptide bond between the group of γ-carboxamides of glutamine residues and the first-order ε-amine groups of different compounds. Transglutaminase is involved in many physiological processes, including coagulation, antibacterial immune reactions and photosynthesis .

HY-E70015

Phosphoenolpyruvate carboxylase, Microorganism PEPC	Others	Others
Phosphoenolpyruvate carboxylase, Microorganism (PEPC) is a carbon dioxide fixing enzyme that in an irreversible manner and in the presence of Mg ²⁺, converts phosphoenolpyruvate and bicarbonate into oxaloacetate and inorganic phosphorus. Phosphoenolpyruvate carboxylase catalyses the primary assimilation of CO(2) in Crassulacean acid metabolism plants. Phosphoenolpyruvate carboxylase plays a major role in setting the day-night pattern of metabolism in plants .

HY-N11409A

Shikimate-3-phosphate lithium	Others	Others
Shikimate-3-phosphate lithium is the salt form of Shikimate-3-phosphate. Shikimate-3-phosphate lithium is a central microbial, parasite and plant metabolite, as a product of the shikimate kinase-catalysed reaction. Shikimate-3-phosphate lithium serves as an enzyme substrate for 5-enolpyruvoyl-shikimate 3-phosphate synthase, which is a target of anti-infectives and of herbicides .

HY-E70033

D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)	Endogenous Metabolite	Metabolic Disease
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine .

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

Cat. No.	Product Name	Type

HY-B2192

Amylase	Biochemical Assay Reagents
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-P2973

Aspergillopepsin I Aspergillus acid protease	Biochemical Assay Reagents
Aspergillopepsin I (Aspergillus acid protease) is an aspartic endopeptidase that catalyses the hydrolysis of peptide bonds in proteins, with broad specificity .

HY-B2193

α-Amylase	Biochemical Assay Reagents
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-P2723

Dextran sucrase	Biochemical Assay Reagents
Dextran sucrase is an extracellular glucosyltransferase (GTF) that catalyses the transfer of D-glucopyranosyl residues from sucrose to dextran .

HY-E70009

Acyl-CoA oxidase ACO	Biochemical Assay Reagents
Acyl-CoA oxidase (ACO) catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids and a major producer of hydrogen peroxide (H₂O₂) .

HY-P2996

NAD(P)H-Nitrate reductase	Biochemical Assay Reagents
NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .

HY-P2968

Bacterial α-Amylase	Biochemical Assay Reagents
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in low molecular weight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .

HY-E70016

Terminal deoxyribonucleotidyltransferase TdT	Biochemical Assay Reagents
Terminal deoxyribonucleotidyltransferase (TdT) catalyses the condensation of deoxyribonucleotide triphosphates onto the 3' hydroxyl ends of DNA strands and adds N-regions to gene segment junctions during V(D)J recombination. Terminal deoxyribonucleotidyltransferase is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Biochemical Assay Reagents
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-E70033

D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)	Biochemical Assay Reagents
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine .

Cat. No.	Product Name	Target	Research Area

HY-P2723

Dextran sucrase	Endogenous Metabolite	Metabolic Disease
Dextran sucrase is an extracellular glucosyltransferase (GTF) that catalyses the transfer of D-glucopyranosyl residues from sucrose to dextran .

HY-P3764

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

HY-P2996

NAD(P)H-Nitrate reductase	Peptides	Others
NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2192

Amylase	Structural Classification Natural Products other families Microorganisms Classification of Application Fields Animals Source classification Metabolic Disease Plants Disease Research Fields	Others
Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .

HY-B2193

α-Amylase	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Others
α-Amylase is a hydrolase enzyme that catalyses the hydrolysis of internal α-1, 4-glycosidic linkages in starch to yield products like glucose and maltose.

HY-E70010

Aldose 1-epimerase mutarotases	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Aldose 1-epimerase (mutarotases) is a key enzyme of carbohydrate metabolism catalysing the interconversion of the α- and β-anomers of hexose sugars such as glucose and galactose. Aldose 1-epimerase is essential for normal carbohydrate metabolism and the production of complex oligosaccharides .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

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