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cis-isomer

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By Targets:	Acyltransferase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (2) HCV (1) HDAC (1) Histone Methyltransferase (1) HSV (1) Interleukin Related (1) Isotope-Labeled Compounds (1) TNF Receptor (1) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Endocrinology (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)

13

Inhibitors & Agonists

5

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended: PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Endogenous Metabolite	Others
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

HY-101648

ACAT-IN-1 cis isomer

Acyltransferase Metabolic Disease

ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC₅₀ of 100 nM.

cis-Lomibuvir cis-VX-222	DNA/RNA Synthesis HCV	Infection
cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a K_d of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀ of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis . cis-Lomibuvir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

trans-VUF25471	Others	Others
trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .

HY-W016814S

(Z)-Aconitic acid-13C6 cis-Aconitic acid-¹³C₆	Isotope-Labeled Compounds	Others
(Z)-Aconitic acid- ¹³C₆ is the ¹³C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

Zuclomiphene citrate	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .

cis-BG47	HDAC Histone Methyltransferase	Neurological Disease
cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

(Z)-Capsaicin Zucapsaicin; Civamide; cis-Capsaicin	TRP Channel HSV	Neurological Disease
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

13-cis-Retinyl acetate 13-cis-Retinol acetate; 13-cis-Vitamin A acetate	Endogenous Metabolite	Endocrinology
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .

13-cis-Vitamin A palmitate 13-cis-Retinyl palmitate	Endogenous Metabolite	Others
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

9-cis-Vitamin A palmitate 9-cis-Retinyl palmitate	Endogenous Metabolite	Others
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

HY-B1617AS1

Zuclomiphene-d5 citrate	Estrogen Receptor/ERR
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].

Cat. No.	Product Name	Category	Target	Chemical Structure

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

13-cis-Retinyl acetate 13-cis-Retinol acetate; 13-cis-Vitamin A acetate	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .

13-cis-Vitamin A palmitate 13-cis-Retinyl palmitate	Zea mays L. Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

9-cis-Vitamin A palmitate 9-cis-Retinyl palmitate	Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

Cat. No.	Product Name	Chemical Structure

HY-W016814S

(Z)-Aconitic acid-13C6
(Z)-Aconitic acid- ¹³C₆ is the ¹³C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- ¹³C₆ (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.

HY-B1617AS1

Zuclomiphene-d5 citrate
Zuclomiphene-d₅ (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].

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