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furocoumarin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) Cytochrome P450 (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Potassium Channel (1) Reactive Oxygen Species (1) Virus Protease (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (1)

10

Inhibitors & Agonists

7

Natural
Products

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2254

(-)-Oxypeucedanin hydrate

(-)-Prangol

(-)-Oxypeucedanin hydrate ((-)-Prangol) is a derivative of furocoumarin isolated from Ducrosia anethifolia .

4,5'-Dimethylangelicin-NHS	DNA/RNA Synthesis	Cancer
4,5'-Dimethylangelicin-NHS is a modified 4,5'-Dimethylangelicin containing an NHS. 4,5'-Dimethylangelicin is an angular furocoumarin with photochemical and photosensitizing properties. 4,5'-Dimethylangelicin can inhibit the DNA and RNA syntheses in Ehrlich ascites tumor cells alter irradiation at 365 nm. 4,5'-Dimethylangelicin has potential as a photochemotherapy agent .

HY-N9523

Gosferol

Others Others

Gosferol is a furocoumarin from the roots of Murraya koenigii .

(-)-Heraclenol	Others	Cancer
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-N7179

7-Hydroxy-5-methoxycoumarin

Others Others

7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant .

Angelicin Maximum Cited Publications 7 Publications Verification Isopsoralen	Apoptosis Virus Protease	Cancer
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	5-HT Receptor Reactive Oxygen Species Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin	Others	Inflammation/Immunology
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight .

Methoxsalen-d3 8-Methoxypsoralen-d₃; Xanthotoxin-d₃; 8-MOP-d₃	Cytochrome P450
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

Oxypeucedanin	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC₅₀ value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation . Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration .

Cat. No.	Product Name	Category	Target	Chemical Structure

Angelicin Maximum Cited Publications 7 Publications Verification Isopsoralen	Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite	5-HT Receptor Reactive Oxygen Species Endogenous Metabolite
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

Gosferol	Structural Classification Classification of Application Fields Euryops arabicus Steud. ex Jaub. & Spach Source classification Other Diseases Rutaceae Murraya koenigii (L.) Spreng Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields	Others
Gosferol is a furocoumarin from the roots of Murraya koenigii .

(-)-Heraclenol	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

7-Hydroxy-5-methoxycoumarin	Source classification Coumarins Phenylpropanoids Plants Convolvulaceae Ipomoea batatas (Linn.) Lamarck	Others
7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant .

5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin	Saussurea medusa Maxim. Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Others
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight .

Oxypeucedanin	Cardiovascular Disease Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields	Potassium Channel Apoptosis
Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC₅₀ value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation . Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration .

Cat. No.	Product Name	Chemical Structure

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

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